NHC Key Laboratory of Food Safety Assessment, Chinese Academy of Medical Science Research Unit (2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China.
NHC Key Laboratory of Food Safety Assessment, Chinese Academy of Medical Science Research Unit (2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China.
NanoImpact. 2022 Jan;25:100368. doi: 10.1016/j.impact.2021.100368. Epub 2021 Nov 26.
The increasing application of zinc oxide nanoparticles (ZnO NPs) in consumer products has raised concerns about the potential health risks in human. It is crucial to understand the toxicokinetic information of ZnO NPs, especially the differences between NPs and non-nano form material. This study investigated the toxicokinetic profile of ZnO NPs and food grade bulk-sized ZnO in rats after single or repeated oral dosages. For single oral administration of ZnO suspensions at 350 mg/kgbw, the Zn content in blood and tissues showed no elevation, the majority of ZnO particles were eliminated via feces within 48 h. For repeated oral exposure to ZnO suspensions at 350 mg/kgbw or ZnSO solution at 700 mg/kgbw for 90 days, elevated Zn levels were observed in liver, kidney, and bone in all three treatment groups, the Zn level recovered to normal level in liver and kidney, but not in bone, after a recovery period. ZnO NPs and bulk-sized ZnO showed similarity in toxicokinetics in rats, regardless of exposure duration or gender. ZnO particles shared a similar biodistribution profile with ZnSO, and were likely to be absorbed mostly in ionic forms.
氧化锌纳米粒子（ZnO NPs）在消费品中的应用日益广泛，这引发了人们对其潜在健康风险的关注。了解 ZnO NPs 的毒代动力学信息至关重要，特别是要了解纳米粒子与非纳米形式材料之间的差异。本研究在大鼠中研究了单次或重复口服 ZnO NPs 和食品级块状 ZnO 后的毒代动力学特征。对于 350mg/kgbw 的 ZnO 混悬液单次口服，血液和组织中的 Zn 含量没有升高，大多数 ZnO 颗粒在 48 小时内通过粪便排出。对于 90 天内以 350mg/kgbw 的 ZnO 混悬液或 700mg/kgbw 的 ZnSO 溶液重复口服暴露，所有三个治疗组的肝脏、肾脏和骨骼中的 Zn 水平均升高，在恢复期后，肝脏和肾脏中的 Zn 水平恢复正常，但骨骼中没有恢复。无论暴露持续时间或性别如何，ZnO NPs 和块状 ZnO 在大鼠中的毒代动力学特征相似。ZnO 颗粒与 ZnSO 具有相似的生物分布特征，可能主要以离子形式被吸收。
