LEITAT Technological Center, Carrer de la Innovació 2, 08225 Terrassa, Barcelona, Spain.
GBP Consulting Ltd, Purton, Swindon SN5 4EJ, United Kingdom.
NanoImpact. 2021 Apr;22:100323. doi: 10.1016/j.impact.2021.100323. Epub 2021 May 15.
In the nanosafety projects funded by the European Commission a large amount of data has been generated on hazard and exposure for a variety of engineered nanomaterials (ENMs) and nano-enabled products (NEPs). However, not all the data generated has been published, nor has all the data been stored in an organised manner (e. g. database) which makes it very difficult for researchers, industry and other stakeholders to use it. This paper provides an inventory of NEPs studied in each of these projects, including relevant information on the NEPs, the life-cycle stages evaluated for each of them and an overview of the projects, which can be used for identifying areas in which there might be data gaps. The purpose of analyzing the nanosafety research done on NEPs was to provide an overview of the products studied compare to what can realistically be found in the market (i.e. the exposure relevant materials that workers, consumers and the environment may be exposed to). The analysis done in all the projects included in the inventory allowed the identification of the need to increase the number of studies with well-established commercialized NEPs, such as ENMs used in tyres or sunscreens. In addition, it was found that, in general, there was a correlation of the different ENMs studied with their respective production relevance (i.e. production volumes), except for silver, which was vastly over-represented, and on the other hand carbon black, which was under-represented. Addittionally, there is a need to improve accessibility to relevant and high quality data produced in all these projects to provide transparency and support to different stakeholder needs.
在欧盟委员会资助的纳米安全项目中，针对各种工程纳米材料（ENMs）和纳米增强产品（NEPs）产生了大量的危害和暴露数据。然而，并非所有生成的数据都已公布，也并非所有数据都以有组织的方式（例如数据库）存储，这使得研究人员、行业和其他利益相关者难以使用这些数据。本文提供了这些项目中研究的 NEPs 的清单，包括有关 NEPs 的相关信息、为它们评估的生命周期阶段以及项目概述，这些信息可用于确定可能存在数据空白的领域。分析针对 NEPs 开展的纳米安全研究的目的是提供已研究产品的概述，以便将其与实际市场上（即工人、消费者和环境可能接触到的与暴露相关的材料）可以找到的产品进行比较。对清单中包含的所有项目进行的分析表明，需要增加对具有良好商业化应用的 NEPs（如用于轮胎或防晒霜的 ENMs）进行研究的数量。此外，还发现，一般来说，所研究的不同 ENMs 与其各自的生产相关性（即生产规模）之间存在相关性，除了银，它的代表性过高，而另一方面是炭黑，它的代表性过低。此外，需要提高这些项目中所有相关高质量数据的可获取性，以提供透明度并满足不同利益相关者的需求。
