Hegedüs L, Hansen J E, Veiergang D, Karstrup S
Dan Med Bull. 1987 Apr;34(2):121-3.
Thyroid function, the clinical occurrence of goitre and thyroid gland volume, ultrasonically determined, were investigated in 310 consecutive untreated patients with hyperthyroidism. Of 173 patients with Graves' disease (39%), 67 had no goitre, while 53 patients (31%) had a normal thyroid volume. Twenty-three of 91 patients with multinodular glands (25%) had no goitre and ten patients (11%) had a normal thyroid volume. Of 46 patients with solitary autonomous nodules (7%), three had no goitre while six (13%) had a normal thyroid volume. Out of all the hyperthyroid patients (30%), 93 had no clinically detectable goitre, and 69 (22%) had a normal thyroid volume. The lack of a goitre in a large portion of patients with hyperthyroidism could be responsible for delayed diagnosis and subsequent treatment of these patients.
对310例未经治疗的连续甲亢患者进行了甲状腺功能、甲状腺肿的临床发生率以及超声测定的甲状腺体积的研究。在173例格雷夫斯病患者（39%）中，67例无甲状腺肿，而53例患者（31%）甲状腺体积正常。在91例多结节性腺体患者（25%）中，23例无甲状腺肿，10例患者（11%）甲状腺体积正常。在46例单发自主性结节患者（7%）中，3例无甲状腺肿，6例（13%）甲状腺体积正常。在所有甲亢患者中（30%），93例临床上未检测到甲状腺肿，69例（22%）甲状腺体积正常。大部分甲亢患者无甲状腺肿可能导致这些患者的诊断延迟及后续治疗延误。
