Letko G, Spormann H, Sokolowski A, Burger P
Dtsch Z Verdau Stoffwechselkr. 1987;47(1):26-32.
For investigations of cell injury during pathogenesis of acute pancreatitis antisera to pancreatic acinar cells were used as experimental tool. Within one hour after intraductal injection of antiserum a strong pancreatic edema was developed. Within 24 h this edema receded to a large extent but at this time there were inflammatory cells scattered in the intra- and periductal region. As a sequel of application of antiserum pancreatic enzymes were released. At 24 h after this application serum activities of alpha-amylase and lipase were significantly increased in comparison to the control and reached that level which was found in a model of acute pancreatitis provoked by pancreatic edema plus short-term ischemia.
为了研究急性胰腺炎发病机制中的细胞损伤，将抗胰腺腺泡细胞抗血清用作实验工具。在导管内注射抗血清后一小时内，胰腺出现严重水肿。24小时内，这种水肿在很大程度上消退，但此时在导管内和导管周围区域有散在的炎症细胞。作为抗血清应用的后续结果，胰腺酶被释放。在应用抗血清24小时后，与对照组相比，血清α-淀粉酶和脂肪酶活性显著增加，并达到了胰腺水肿加短期缺血诱发的急性胰腺炎模型中的水平。
