Pagano G, Cavallo-Perin P, Cavalot F, Dall'Omo A M, Masciola P, Suriani R, Amoroso A, Curtoni S E, Borelli I, Lenti G
Diabetes. 1987 Jul;36(7):859-63. doi: 10.2337/diab.36.7.859.
The 1-yr incidence of insulin-dependent diabetes mellitus (IDDM) in a population of the Piedmont and Aosta Valley area of Italy was recorded. Anti-virus antibodies (e.g., Coxsackie B1-6, mumps, cytomegalovirus), islet cell antibodies (ICAs), and HLA-A, -B, -C, and -DR were determined in 74 IDDM patients (38 males, 36 females) and in controls. Total IDDM incidence was 5.0/100,000, and the incidence for those less than 20 yr of age was 11.6/100,000. Anti-virus antibody frequency was not different in IDDM patients and controls. ICAs were present in 58% of IDDM patients at onset and in 30% after 12 mo, and complement-fixing ICAs were found in 39 and 17%, respectively. IDDM was significantly and positively associated with DR3/DR4 and negatively associated with DR2 and DR5. ICA frequency was significantly higher in DR3/DR4 heterozygote patients than in patients without DR3 and DR4. These results suggest that in this IDDM population viral etiology is not evident, ICAs offer only a partial pathogenetic explanation, and genetic and immunologic heterogeneity is evident.
记录了意大利皮埃蒙特和奥斯塔山谷地区人群中胰岛素依赖型糖尿病（IDDM）的1年发病率。在74例IDDM患者（38例男性，36例女性）及对照人群中检测了抗病毒抗体（如柯萨奇B1 - 6、腮腺炎、巨细胞病毒）、胰岛细胞抗体（ICA）以及HLA - A、- B、- C和 - DR。IDDM总发病率为5.0/100,000，20岁以下人群发病率为11.6/100,000。IDDM患者和对照人群的抗病毒抗体频率无差异。发病时58%的IDDM患者存在ICA，12个月后这一比例为30%，补体结合性ICA分别为39%和17%。IDDM与DR3/DR4显著正相关，与DR2和DR5负相关。DR3/DR4杂合子患者的ICA频率显著高于无DR3和DR4的患者。这些结果表明，在该IDDM人群中病毒病因不明显，ICA仅提供部分发病机制解释，且遗传和免疫异质性明显。
