Sami-Sabinsa Group Limited, 19/1&19/2, I Main, II Phase, Peenya Industrial Area, Bangalore 560-058, Karnataka, India.
Sabinsa Corporation, 20 Lake Drive, East Windsor, NJ 08520, USA.
Int J Mol Sci. 2022 Apr 27;23(9):4809. doi: 10.3390/ijms23094809.
The SARS-CoV-2 infection is a highly contagious viral infection, which has claimed millions of lives in the last two years. The infection can cause acute respiratory distress, myocarditis, and systemic inflammatory response in severe cases. The interaction of the viral spike protein with the angiotensin-converting enzyme in various tissues causes damage to vital organs and tissues, leading to complications in the post-infection period. Vaccines and antiviral drugs have improved patient response to the infection, but the long-term effect on vital organs is still unknown. Investigations are now focused on supportive nutrient therapies, which can mitigate the susceptibility as well as the long-term complications of COVID-19. Selenium is one such micronutrient that plays a vital role in preventing oxidative stress induced by the virus. Further, selenium is important for effective immune response, controlling systemic inflammation, and maintain overall health of humans. We examine the role of selenium in various aspects of SARS-CoV-2 infection and address the importance of selenium supplementation in reducing the susceptibility and severity of infection in this review.
新型冠状病毒感染是一种高度传染性的病毒感染，在过去两年中已夺走数百万人的生命。在严重的情况下，感染会导致急性呼吸窘迫、心肌炎和全身炎症反应。病毒刺突蛋白与各种组织中的血管紧张素转换酶相互作用，导致重要器官和组织受损，导致感染后出现并发症。疫苗和抗病毒药物改善了患者对感染的反应，但对重要器官的长期影响仍不清楚。目前的研究重点是支持性营养疗法，这些疗法可以减轻 COVID-19 的易感性和长期并发症。硒就是这样一种微量营养素，它在预防病毒引起的氧化应激方面起着至关重要的作用。此外，硒对于有效的免疫反应、控制全身炎症和维持人类整体健康也很重要。我们在本综述中检查了硒在新型冠状病毒感染各个方面的作用，并讨论了硒补充剂在降低感染易感性和严重程度方面的重要性。
