星系 Dnpatterntools 用于核小体定位序列模式的计算分析。
Galaxy Dnpatterntools for Computational Analysis of Nucleosome Positioning Sequence Patterns.
机构信息
Department of Human and Medical Genetics, Biomedical Science Institute, Vilnius University, LT-08661 Vilnius, Lithuania.
Department of Systems Analysis, Faculty of Informatics, Vytautas Magnus University, LT-44404 Kaunas, Lithuania.
出版信息
Int J Mol Sci. 2022 Apr 28;23(9):4869. doi: 10.3390/ijms23094869.
Nucleosomes are basic units of DNA packing in eukaryotes. Their structure is well conserved from yeast to human and consists of the histone octamer core and 147 bp DNA wrapped around it. Nucleosomes are bound to a majority of the eukaryotic genomic DNA, including its regulatory regions. Hence, they also play a major role in gene regulation. For the latter, their precise positioning on DNA is essential. In the present paper, we describe Galaxy dnpatterntools-software package for nucleosome DNA sequence analysis and mapping. This software will be useful for computational biologists practitioners to conduct more profound studies of gene regulatory mechanisms.
核小体是真核生物中 DNA 包装的基本单位。从酵母到人，其结构都得到了很好的保守，由组蛋白八聚体核心和 147bp 的 DNA 缠绕组成。核小体与真核生物基因组 DNA 的大部分结合，包括其调控区。因此，它们在基因调控中也起着主要作用。对于后者，它们在 DNA 上的精确定位是必不可少的。在本文中，我们描述了 Galaxy dnpatterntools-软件包，用于核小体 DNA 序列分析和作图。该软件将对计算生物学家的从业者进行更深入的基因调控机制研究很有用。
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