Ostermann H, van de Loo J
Haemostasis. 1986;16(6):386-416. doi: 10.1159/000215317.
Diabetes mellitus is associated with a variety of vascular complications like diabetic retinopathy, myocardial infarction, stroke and peripheral vessel disease. These complications are of utmost importance because they lead to disability and premature death of the patients. The pathogenesis of these lesions has been thought to depend at least partly on defects in the hemostatic system. Many alterations of the coagulation and the fibrinolytic system as well as of the reaction of platelets have been found in diabetics. In general these tend to suggest a state of slightly activated coagulation, of increased platelet reactivity and of decreased fibrinolysis. However, no conclusive picture of the role of hemostasis in the development of vascular lesions in diabetics has emerged yet, as contradictive results have been found by many investigators. The aim of this review article is to sum up the knowledge that has accumulated in the last years in controlled clinical trials concerning the state of the diabetic hemostatic system.
糖尿病与多种血管并发症相关，如糖尿病视网膜病变、心肌梗死、中风和外周血管疾病。这些并发症至关重要，因为它们会导致患者残疾和过早死亡。这些病变的发病机制被认为至少部分取决于止血系统的缺陷。在糖尿病患者中发现了凝血和纤维蛋白溶解系统以及血小板反应的许多改变。总体而言，这些往往提示存在轻度激活的凝血状态、血小板反应性增加和纤维蛋白溶解减少。然而，由于许多研究者发现了相互矛盾的结果，关于止血在糖尿病血管病变发展中的作用尚未形成定论。这篇综述文章的目的是总结过去几年在关于糖尿病止血系统状态的对照临床试验中积累的知识。
