Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery, A.P. Avtsyn Research Institute of Human Morphology", 117418 Moscow, Russia.
Int J Mol Sci. 2022 May 5;23(9):5141. doi: 10.3390/ijms23095141.
Crohn's disease remains one of the challenging problems of modern medicine, and the development of new and effective and safer treatments against it is a dynamic field of research. To make such developments possible, it is important to understand the pathologic processes underlying the onset and progression of Crohn's disease at the molecular and cellular levels. During the recent years, the involvement of mitochondrial dysfunction and associated chronic inflammation in these processes became evident. In this review, we discuss the published works on pathogenetic models of Crohn's disease. These models make studying the role of mitochondrial dysfunction in the disease pathogenesis possible and advances the development of novel therapies.
克罗恩病仍然是现代医学面临的难题之一，开发新的、有效和更安全的治疗方法是一个充满活力的研究领域。为了实现这些发展，了解克罗恩病发病和进展的分子和细胞水平的病理过程非常重要。近年来，线粒体功能障碍及其相关的慢性炎症在这些过程中的参与变得明显。在这篇综述中，我们讨论了关于克罗恩病发病机制模型的已发表作品。这些模型使研究线粒体功能障碍在疾病发病机制中的作用成为可能，并推进了新疗法的开发。
