Bottorff M B, Pieper J A, Boucher B A, Hoon T J, Ramanathan J, Sibai B M
Eur J Clin Pharmacol. 1987;31(6):719-22. doi: 10.1007/BF00541302.
The effect of preeclampsia on the binding of lidocaine to serum proteins was studied in 25 term parturients with severe preeclampsia and in 21 normal parturients serving as controls. There were no statistically significant differences in mean lidocaine free fraction, binding ratio, or serum AAG levels in the control vs preeclamptic patients, respectively. Binding ratio was strongly correlated with AAG concentration for the control (r = 0.91) and preeclamptic (r = 0.85) patients. A statistically significant difference was observed in the slopes of the lines relating binding ratio to AAG. Preeclampsia had little affect on serum AAG concentrations and lidocaine binding ratio. Preeclampsia may alter the interaction of lidocaine with binding sites on AAG without a significant change in lidocaine free fraction.
研究了子痫前期对利多卡因与血清蛋白结合的影响，选取25例重度子痫前期足月产妇和21例正常产妇作为对照。对照产妇与子痫前期产妇的平均游离利多卡因分数、结合率或血清α1-酸性糖蛋白（AAG）水平分别无统计学显著差异。对照产妇（r = 0.91）和子痫前期产妇（r = 0.85）的结合率与AAG浓度密切相关。观察到结合率与AAG关系曲线的斜率存在统计学显著差异。子痫前期对血清AAG浓度和利多卡因结合率影响不大。子痫前期可能改变利多卡因与AAG结合位点的相互作用，而游离利多卡因分数无显著变化。
