Edwards D J, Lalka D, Cerra F, Slaughter R L
Clin Pharmacol Ther. 1982 Jan;31(1):62-7. doi: 10.1038/clpt.1982.10.
Alpha 1-Acid glycoprotein (AAG) concentrations were measured every 2 to 3 days in eight trauma patients and seven healthy subjects for approximately 3 wk. Mean AAG concentrations in the trauma patients rose from 100 mg/dl to a peak value of 243 mg/dl at 10 to 14 days. AAG levels averaged more than 200 mg/dl at 15 to 21 days. Mean AAG concentration in healthy subjects was 70 mg/dl with little inter- or intraindividual variability. Lidocaine was added to all serum samples from four of the patients and to selected samples from all of the healthy subjects and protein binding was determined. The binding ratio (bound concentration/free concentration) correlated strongly with AAG concentration in the trauma patients (r = 0.92), in the healthy subjects (r = 0.84), and in both groups combined (r = 0.96). AAG concentration and binding ratio for each of the four patients individually also correlated (P less than 0.05 in all cases). The change in free fraction associated with this increase in AAG was approximately doubled in each patient. Similar findings with drugs commonly used in trauma patients would be expected to alter serum concentration-response relationships significantly.
对8名创伤患者和7名健康受试者每隔2至3天测量一次α1-酸性糖蛋白（AAG）浓度，持续约3周。创伤患者的AAG平均浓度从100mg/dl升至10至14天时的峰值243mg/dl。在15至21天时，AAG水平平均超过200mg/dl。健康受试者的AAG平均浓度为70mg/dl，个体间和个体内差异很小。将利多卡因添加到4名患者的所有血清样本以及所有健康受试者的选定样本中，并测定蛋白结合率。在创伤患者中（r = 0.92）、健康受试者中（r = 0.84）以及两组合并后（r = 0.96），结合率（结合浓度/游离浓度）与AAG浓度密切相关。4名患者各自的AAG浓度和结合率也具有相关性（所有情况下P均小于0.05）。与AAG升高相关的游离分数变化在每名患者中大约增加了一倍。预计创伤患者常用药物的类似发现会显著改变血清浓度-反应关系。
