Iványi T, Laczi F, Kovács G L, Szabó G, Janáky T, Telegdy G, László F A
Exp Clin Endocrinol. 1986 Dec;88(3):303-8. doi: 10.1055/s-0029-1210610.
Experiments were designed to investigate the effects of the intracerebroventricular administration of dopamine (DA) and a DA antagonist (pimozide) on the immunoreactive-vasopressin (IR-VP) contents of the rat magnocellular nuclei (MCN), neurohypophysis (NH) and plasma. The IR-VP levels in the MCN and NH were decreased 5 min after administration of DA in a dose of 20 nmol, but that in the plasma was increased. This effect was not observed after pretreatment with pimozide. Administration of pimozide alone did not affect the IR-VP contents of the MCN, NH or plasma. The results suggest that DA given icv. has a stimulatory effect on VP release from the neurohypophysial system.
实验旨在研究脑室内注射多巴胺（DA）和DA拮抗剂匹莫齐特对大鼠大细胞神经核（MCN）、神经垂体（NH）和血浆中免疫反应性血管加压素（IR-VP）含量的影响。注射20 nmol剂量的DA后5分钟，MCN和NH中的IR-VP水平降低，但血浆中的IR-VP水平升高。匹莫齐特预处理后未观察到此效应。单独注射匹莫齐特不影响MCN、NH或血浆中的IR-VP含量。结果表明，脑室内注射DA对神经垂体系统释放VP有刺激作用。
