Grzywa M
Exp Clin Endocrinol. 1986 Dec;88(3):325-33. doi: 10.1055/s-0029-1210613.
The effect of body weight excess and hyperlipidemia on stimulated growth hormone (GH) secretion and serum somatomedin activity (SSA) has been investigated. Among 40 obese men gradually impairment of GH secretory response during the insulin hypoglycemia test was shown. Propranolol-L-DOPA administration elicited satisfactory GH secretory response only in the subgroup of patients with the mild weight excess. SSA was found to be in the normal range among the whole group of obese patients, however, it was significantly depressed in subjects with average weight excess higher than 100%. Obese men with hypertriglyceridemia and hypercholesterolemia presented low SSA even when their weight excess was relatively moderate, i.e., 52% and 57%, respectively.
研究了体重超标和高脂血症对刺激生长激素（GH）分泌及血清生长调节素活性（SSA）的影响。在40名肥胖男性中，胰岛素低血糖试验期间显示出GH分泌反应逐渐受损。普萘洛尔-L-多巴给药仅在轻度体重超标的患者亚组中引发了令人满意的GH分泌反应。在整个肥胖患者组中，SSA被发现处于正常范围内，然而，在平均体重超标高于100%的受试者中，SSA显著降低。患有高甘油三酯血症和高胆固醇血症的肥胖男性即使体重超标相对适中，即分别为52%和57%，也表现出低SSA。
