Laurian L, Oberman Z, Hoerer E, Wiznitzer T, Harell A
Isr J Med Sci. 1982 May;18(5):625-9.
The response of plasma growth hormone (GH) to 0.5 g L-dopa was studied in 17 obese nondiabetic subjects and in 6 normal-weight subjects, aged 16 to 46 yr. The test was repeated after the obese subjects were thinned 12 to 50 kg, either with a hypocaloric diet or by a jejunoileal shunt. All the obese subjects had a blunted response to L-dopa stimulation. Nine of the thinned obese continued to exhibit the same blunted GH response, while the other eight responded with a significant GH rise after L-dopa stimulation, although the increase was smaller than that in the controls. No correlation between the initial or final weight or the extent of weight loss and the response to L-dopa was observed. It is assumed that a hypothalamic underresponsiveness is responsible for the blunted response in the obese subjects and its persistence in some of the thinned obese.
在17名年龄在16至46岁的肥胖非糖尿病受试者和6名正常体重受试者中，研究了血浆生长激素（GH）对0.5 g左旋多巴的反应。在肥胖受试者通过低热量饮食或空肠回肠分流术减轻12至50 kg体重后，重复进行该测试。所有肥胖受试者对左旋多巴刺激的反应均减弱。9名体重减轻的肥胖受试者继续表现出相同的GH反应减弱，而其他8名受试者在左旋多巴刺激后GH显著升高，尽管升高幅度小于对照组。未观察到初始或最终体重、体重减轻程度与对左旋多巴反应之间的相关性。据推测，下丘脑反应不足是肥胖受试者反应减弱及其在一些体重减轻的肥胖受试者中持续存在的原因。
