Centre of Excellence for Nutrition, North-West University, Potchefstroom 2520, South Africa.
Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom 2520, South Africa.
Int J Environ Res Public Health. 2022 Apr 21;19(9):5061. doi: 10.3390/ijerph19095061.
Obesity is associated with an increased cardiometabolic risk, but some individuals maintain metabolically healthy obesity (MHO). The aims were to follow a cohort of black South African adults over a period of 10 years to determine the proportion of the group that maintained MHO over 10 years, and to compare the metabolic profiles of the metabolically healthy and metabolically unhealthy groups after the follow-up period. The participants were South African men ( = 275) and women ( = 642) from the North West province. The prevalence of obesity and the metabolic syndrome increased significantly. About half of the metabolically healthy obese (MHO) adults maintained MHO over 10 years, while 46% of the women and 43% of men became metabolically unhealthy overweight/obese (MUO) at the end of the study. The metabolic profiles of these MHO adults were similar to those of the metabolically healthy normal weight (MHNW) group in terms of most metabolic syndrome criteria, but they were more insulin resistant; their CRP, fibrinogen, and PAI-1act were higher and HDL-cholesterol was lower than the MHNW group. Although the metabolic profiles of the MUO group were less favourable than those of their counterparts, MHO is a transient state and is associated with increased cardiometabolic risk.
肥胖与心血管代谢风险增加有关，但有些个体仍保持代谢健康型肥胖（MHO）。本研究旨在对南非黑人成年人进行为期 10 年的随访，以确定在 10 年内保持 MHO 的人群比例，并比较随访后代谢健康组和代谢不健康组的代谢特征。参与者为来自西北省的南非男性（n = 275）和女性（n = 642）。肥胖和代谢综合征的患病率显著增加。约一半的代谢健康型肥胖（MHO）成年人在 10 年内仍保持 MHO，而研究结束时，46%的女性和 43%的男性成为代谢不健康的超重/肥胖（MUO）。这些 MHO 成年人的代谢特征与代谢健康的正常体重（MHNW）组在大多数代谢综合征标准方面相似，但他们的胰岛素抵抗更严重；他们的 CRP、纤维蛋白原和 PAI-1act 更高，HDL-胆固醇水平更低。尽管 MUO 组的代谢特征不如其对照组，但 MHO 是一种短暂状态，与增加的心血管代谢风险相关。
