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[酒精对人心肌亚细胞组分钙和蛋白质含量的影响]

[Effect of alcohol on the calcium and protein content of the subcellular fractions of the human myocardium].

作者信息

Sopka N V, Bel'chenko D I, Chelnokov V S

出版信息

Farmakol Toksikol. 1987 Jan-Feb;50(1):107-12.

PMID:3556544
Abstract

It was established that in the persons who had died from acute ethanol intoxication the processes of calcium compartmentalization in myocardiocytes are disordered and characterized by a decrease of calcium content in mitochondria and sarcoplasmic reticulum and an increase of its concentration in the supernatant fluid. Alcohol-induced changes of calcium compartmentalization in myocardiocytes may cause cardiac disorders and be, in particular, one of the possible links in the thanatogenesis of sudden death.

摘要

已经确定,在死于急性乙醇中毒的人当中,心肌细胞中的钙分隔过程紊乱,其特征是线粒体和肌浆网中的钙含量降低,而其在上清液中的浓度增加。酒精引起的心肌细胞钙分隔变化可能导致心脏疾病,尤其是猝死发生机制中可能的环节之一。

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