Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Emerging Infections and Parasitology Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Nutrients. 2022 Apr 20;14(9):1708. doi: 10.3390/nu14091708.
Infections and persistent immunological activation are linked to increased kynurenine (KYN) and the KYN-to-Tryptophan (TRP) or KT ratio and may be critical factors in undernutrition. We sought to determine the association between the KT ratio and adult malnutrition, as well as investigate if nutritional supplementation had any influence on the decrease of the KT ratio. A total of 525 undernourished adults aged 18-45 years were recruited and provided a nutrition intervention for 60 feeding days. TRP and KYN concentrations were determined from plasma samples using LC-MS/MS. At baseline, the median (interquartile range (IQR)) TRP, KYN and KT ratios were 24.1 (17.6, 34.3) µmol/L, 0.76 (0.53, 1.18) µmol/L and 30.9 (24.5, 41.7), respectively. Following intervention, the median (IQR) KYN and KT ratios were significantly reduced to 0.713 (0.46, 1.12) µmol/L and 27.5 (21.3, 35.8). The KT ratio was found to be inversely linked with adult BMI (coefficient: -0.09; 95% CI: -0.18, 0.004; -value = 0.06) but not statistically significant. Additionally, Plasma CRP was correlated positively, while LRP1 was inversely correlated with the KT ratio. Our data suggest that in Bangladeshi adults, the KT ratio is not related to the pathophysiology of malnutrition but correlated with inflammatory and anti-inflammatory biomarkers, and the ratio can be reduced by a nutrition intervention.
感染和持续的免疫激活与犬尿氨酸（KYN）的增加以及 KYN 与色氨酸（TRP）或 KT 比值有关，并且可能是营养不良的关键因素。我们试图确定 KT 比值与成人营养不良之间的关联，并研究营养补充是否对 KT 比值的降低有任何影响。共招募了 525 名年龄在 18-45 岁之间的营养不良成年人，并对他们进行了 60 天的营养干预。使用 LC-MS/MS 从血浆样本中测定 TRP 和 KYN 浓度。在基线时，TRP、KYN 和 KT 比值的中位数（四分位距（IQR））分别为 24.1（17.6，34.3）µmol/L、0.76（0.53，1.18）µmol/L 和 30.9（24.5，41.7）。干预后，KYN 和 KT 比值的中位数（IQR）分别显著降低至 0.713（0.46，1.12）µmol/L 和 27.5（21.3，35.8）。发现 KT 比值与成人 BMI 呈负相关（系数：-0.09；95%CI：-0.18，0.004；-值=0.06），但无统计学意义。此外，血浆 CRP 与 KT 比值呈正相关，而 LRP1 与 KT 比值呈负相关。我们的数据表明，在孟加拉国成年人中，KT 比值与营养不良的病理生理学无关，但与炎症和抗炎生物标志物相关，并且营养干预可以降低该比值。
