Willatt D J, Jackson S R, McCormick M S, Lubsen H, Michaels L, Stell P M
Eur J Surg Oncol. 1987 Apr;13(2):131-7.
The present UICC classification of postcricoid cancer is based on directions of tumour spread which are uncommon and difficult to assess clinically. The classification takes no note of spread into the cervical oesophagus and fails to correlate staging with survival. The aim of this study was to assess the value of other criteria, including vocal cord paralysis and tumour length, in staging 157 patients with postcricoid cancer. Both vocal cord paralysis and tumour length could be assessed in most patients, and correlated with the mode of treatment. Generalized Linear Interactive Modelling (GLIM) identified vocal cord paralysis (P less than 0.001), performance status (P less than 0.025) and the interaction of length and histological grade (P less than 0.05) as significant predictors of survival. None of these variables is included in the current UICC classification.
目前国际抗癌联盟（UICC）对环状软骨后癌的分类是基于肿瘤扩散方向，而这些方向并不常见且临床评估困难。该分类未考虑肿瘤向颈段食管的扩散情况，也未将分期与生存率相关联。本研究的目的是评估其他标准（包括声带麻痹和肿瘤长度）在对157例环状软骨后癌患者进行分期中的价值。大多数患者的声带麻痹和肿瘤长度均可评估，且与治疗方式相关。广义线性交互模型（GLIM）确定声带麻痹（P＜0.001）、体能状态（P＜0.025）以及长度与组织学分级的交互作用（P＜0.05）是生存的重要预测因素。当前的UICC分类中未纳入这些变量中的任何一个。
