School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Department of Dermatology, Cardinal Tien Hospital, New Taipei City 23148, Taiwan.
Molecules. 2022 Apr 19;27(9):2610. doi: 10.3390/molecules27092610.
Atopic dermatitis (eczema) is a condition that makes skin red and itchy. Though common in children, the condition can occur at any age. Atopic dermatitis is persistent (chronic) and tends to recur periodically. It may be accompanied by asthma or hay fever. No cure has been found for eczema. Therefore, it is very important to develop ingredients that aid the prevention and treatment of atopic dermatitis. Cycloheterophyllin is derived from and has antioxidant and anti-inflammatory activities. However, it still is not understood whether cycloheterophyllin is an anti-atopic dermatitis agent. Keratinocytes (HaCaT cells) and BALB/c mice for inducing AD-like cutaneous lesions were used to evaluate the potential of cycloheterophyllin as an anti-atopic dermatitis agent. The release of pro-inflammatory cytokines induced by treatment of TNF-α/IFN-γ was reduced after pretreatment with cycloheterophyllin. The inhibitory effects could be a contribution from the effect of the MAP kinases pathway. Moreover, the symptoms of atopic dermatitis (such as red skin and itching) were attenuated by pretreatment with cycloheterophyllin. Epidermal hyperplasia and mast cell infiltration were decreased in the histological section. Finally, damage to the skin barrier was also found to recover through assessment of transepidermal water loss. Taken together, prenylflavone-cycloheterophyllin from is a potential anti-atopic dermatitis ingredient that can be used in preventing or treating the condition.
特应性皮炎（湿疹）是一种会导致皮肤发红和瘙痒的疾病。虽然常见于儿童，但任何年龄段都可能发生。特应性皮炎是持续性的（慢性的），并且往往会周期性复发。它可能伴有哮喘或花粉热。目前还没有找到治疗湿疹的方法。因此，开发有助于预防和治疗特应性皮炎的成分非常重要。环异海松素来源于，具有抗氧化和抗炎活性。然而，目前尚不清楚环异海松素是否是一种抗特应性皮炎的药物。角朊细胞（HaCaT 细胞）和 BALB/c 小鼠用于诱导类似特应性皮炎的皮肤损伤，以评估环异海松素作为抗特应性皮炎药物的潜力。用 TNF-α/IFN-γ 处理后，环异海松素预处理可减少促炎细胞因子的释放。这种抑制作用可能是 MAP 激酶途径作用的结果。此外，环异海松素预处理可减轻特应性皮炎的症状（如皮肤发红和瘙痒）。组织学切片中表皮增生和肥大细胞浸润减少。最后，通过评估经皮水分流失发现，皮肤屏障的损伤也得到了恢复。综上所述，来源于 的 7-甲氧基-8-异戊烯基黄酮-环异海松素是一种有潜力的抗特应性皮炎成分，可用于预防或治疗该疾病。
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