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从珊瑚虫中分离得到的-Oxyzoanthamine 具有抗特应性皮炎活性。

Anti-Atopic Dermatitis Activity of -Oxyzoanthamine Isolated from Zoanthid.

机构信息

School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan.

Department of Dermatology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan.

出版信息

Mar Drugs. 2023 Aug 12;21(8):447. doi: 10.3390/md21080447.

DOI:10.3390/md21080447
PMID:37623728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10456062/
Abstract

Atopic dermatitis (AD, eczema) is a condition that causes dry, itchy, and inflamed skin and occurs most frequently in children but also affects adults. However, common clinical treatments provide limited relief and have some side effects. Therefore, there is a need to develop new effective therapies to treat AD. -oxyzoanthamine is a small molecule alkaloid isolated from Formosan zoanthid. Relevant studies have shown that zoanthamine alkaloids have many pharmacological and biological activities, including anti-lymphangiogenic functions. However, there are no studies on the use of -oxyzoanthamine on the skin. In this paper, -oxyzoanthamine has been shown to have potential in the treatment of atopic dermatitis. Through in vitro studies, it was found that -oxyzoanthamine inhibited the expression of cytokines in TNF-α/IFN-γ-stimulated human keratinocyte (HaCaT) cells, and it reduced the phosphorylation of MAPK and the NF-κB signaling pathway. Atopic dermatitis-like skin inflammation was induced in a mouse model using 2,4-dinitrochlorobenzene (DNCB) in vivo. The results showed that -oxyzoanthamine significantly decreased skin barrier damage, scratching responses, and epidermal hyperplasia induced by DNCB. It significantly reduced transepidermal water loss (TEWL), erythema, ear thickness, and spleen weight, while also increasing surface skin hydration. These results indicate that -oxyzoanthamine from zoanthid has good potential as an alternative medicine for treating atopic dermatitis or other skin-related inflammatory diseases.

摘要

特应性皮炎（AD，湿疹）是一种导致皮肤干燥、瘙痒和炎症的疾病，最常发生在儿童，但也影响成年人。然而，常见的临床治疗方法提供的缓解有限，并且有一些副作用。因此，需要开发新的有效疗法来治疗 AD。-氧代氧杂氮卓胺是一种从小立碗藓珊瑚中分离得到的小分子生物碱。相关研究表明，氧杂氮卓生物碱具有许多药理和生物学活性，包括抗淋巴管生成功能。然而，目前尚无关于 -氧代氧杂氮卓胺在皮肤方面应用的研究。本文表明 -氧代氧杂氮卓胺在治疗特应性皮炎方面具有潜力。通过体外研究发现，-氧代氧杂氮卓胺抑制 TNF-α/IFN-γ 刺激的人角质形成细胞（HaCaT）细胞中细胞因子的表达，并降低 MAPK 和 NF-κB 信号通路的磷酸化。在体内使用 2,4-二硝基氯苯（DNCB）诱导小鼠模型产生特应性皮炎样皮肤炎症。结果表明，-氧代氧杂氮卓胺显著减轻 DNCB 诱导的皮肤屏障损伤、搔抓反应和表皮增生。它还显著降低经皮水分丢失（TEWL）、红斑、耳厚和脾重，同时增加表面皮肤水合作用。这些结果表明，小立碗藓珊瑚中的 -氧代氧杂氮卓胺具有作为治疗特应性皮炎或其他皮肤相关炎症性疾病的替代药物的良好潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/0bff7f944f7f/marinedrugs-21-00447-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/d7d34e82f278/marinedrugs-21-00447-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/cfd433fa4bca/marinedrugs-21-00447-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/af62a4468b70/marinedrugs-21-00447-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/d104123e4de2/marinedrugs-21-00447-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/28e3d72c0563/marinedrugs-21-00447-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/c5db7657bfc9/marinedrugs-21-00447-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/2091c3ff8f53/marinedrugs-21-00447-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/0bff7f944f7f/marinedrugs-21-00447-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/d7d34e82f278/marinedrugs-21-00447-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/cfd433fa4bca/marinedrugs-21-00447-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/af62a4468b70/marinedrugs-21-00447-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/d104123e4de2/marinedrugs-21-00447-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/28e3d72c0563/marinedrugs-21-00447-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/c5db7657bfc9/marinedrugs-21-00447-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/2091c3ff8f53/marinedrugs-21-00447-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb0/10456062/0bff7f944f7f/marinedrugs-21-00447-g008.jpg

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