Department of Antibiotics, Federal University of Pernambuco (UFPE), Av. Artur de Sá, s/n, Cidade Universitária, Recife 54740-520, PE, Brazil.
Laboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri (URCA), 1161 Cel. Antonio Luiz Avenue, Crato 63105-000, CE, Brazil.
Molecules. 2022 Apr 25;27(9):2753. doi: 10.3390/molecules27092753.
Cymbopogon winterianus, known as “citronella grass”, is an important aromatic and medicinal tropical herbaceous plant. The essential oil of C. winterianus (EOCw) is popularly used to play an important role in improving human health due to its potential as a bioactive component. The present study aimed to identify the components of the essential oil of C. winterianus and verify its leishmanicidal and trypanocidal potential, as well as the cytotoxicity in mammalian cells, in vitro. The EOCw had geraniol (42.13%), citronellal (17.31%), and citronellol (16.91%) as major constituents. The essential oil only exhibited significant cytotoxicity in mammalian fibroblasts at concentrations greater than 250 μg/mL, while regarding antipromastigote and antiepimastigote activities, they presented values considered clinically relevant, since both had LC50 < 62.5 μg/mL. It can be concluded that this is a pioneer study on the potential of the essential oil of C. winterianus and its use against the parasites T. cruzi and L. brasiliensis, and its importance is also based on this fact. Additionally, according to the results, C. winterianus was effective in presenting values of clinical relevance and low toxicity and, therefore, an indicator of popular use.
香茅草，又称“柠檬草”，是一种重要的芳香药用热带草本植物。香茅草精油（EOCw）因其作为生物活性成分的潜力而被广泛用于改善人类健康方面发挥着重要作用。本研究旨在鉴定香茅草精油的成分，并验证其杀利什曼原虫和杀锥虫的潜力，以及在体外对哺乳动物细胞的细胞毒性。EOCw 的主要成分是香叶醇（42.13%）、香茅醛（17.31%）和香茅醇（16.91%）。该精油仅在浓度大于 250 μg/mL 时对哺乳动物成纤维细胞表现出显著的细胞毒性，而对于抗前鞭毛体和抗无鞭毛体活性，其表现出被认为具有临床相关性的数值，因为两者的 LC50<62.5 μg/mL。可以得出结论，这是一项关于香茅草精油的潜在用途及其对寄生虫 T. cruzi 和 L. brasiliensis 的潜在用途的开创性研究，其重要性也基于这一事实。此外，根据结果，香茅草在表现出具有临床相关性和低毒性的数值方面是有效的，因此是一种受欢迎的用途的指标。
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