Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.
Molecules. 2022 May 4;27(9):2939. doi: 10.3390/molecules27092939.
Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. Hence, under mild conditions, 3-chloroperbenzoic acid was used to cleave the carbon-sulfur bond of the Biginelli hybrids 5,6-dihydropyrimidin-4(3)-ones. This approach led to thirteen novel dihydrouracils synthesized in moderate-to-high yields (32-99%).
二氢尿嘧啶是尿嘧啶分解代谢中的关键中间产物。尿嘧啶及其核苷尿苷的重要性促使科学家合成新型二氢尿嘧啶。在本文中，我们提出了一种新颖、快速且有效的二氢尿嘧啶合成方法。因此，在温和条件下，使用 3-氯过氧苯甲酸裂解了比格利尼杂环 5,6-二氢嘧啶-4(3)-酮的碳-硫键。该方法得到了 13 种新型二氢尿嘧啶，收率中等至高产（32-99%）。
