Department of Chemistry, Alzahra University, Tehran, Iran.
Department of Chemistry, Razi University, Kermanshah, 67149, Iran.
Mol Divers. 2018 Aug;22(3):751-767. doi: 10.1007/s11030-018-9841-4. Epub 2018 Jun 23.
The Biginelli reaction, involving a three-component reaction of an aromatic aldehyde, urea and ethyl acetoacetate, has emerged as an extremely useful synthetic tool to organic chemists for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones and related heterocyclic compounds. In the past decades, the asymmetric variants of this reaction have been at the forefront of investigations in several research groups. In 2013, we highlighted the developments occurred in the asymmetric version of the Biginelli reaction. This review article focuses on the recent developments of asymmetric Biginelli reaction covers the literature going back to 2012.
Biginelli 反应是一种三组分反应，涉及芳香醛、尿素和乙酰乙酸乙酯，它已成为有机化学家合成 3,4-二氢嘧啶-2(1H)-酮和相关杂环化合物的极其有用的合成工具。在过去的几十年中，该反应的不对称变体一直是几个研究小组研究的前沿。2013 年，我们重点介绍了不对称 Biginelli 反应的发展。本文综述了不对称 Biginelli 反应的最新进展，涵盖了 2012 年以来的文献。
