全甲状腺切除术中促甲状腺激素、甲状腺素、三碘甲状腺原氨酸及甲状腺球蛋白水平的变化
Changes in TSH, T4, T3 and Thyroglobulin Levels throughout Total Thyroidectomy.
作者信息
Senese Nora, Lechien Jérôme R, Poppe Kris, Rodriguez Alexandra, Dequanter Didier
机构信息
Department of Otolaryngology-Head & Neck surgery, CHU Saint Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium.
Department of Thoracic-Head & Neck Surgery, Centre Oscar Lambret, 59000 Lille, France.
出版信息
J Clin Med. 2022 Apr 25;11(9):2416. doi: 10.3390/jcm11092416.
INTRODUCTION
To assess the impact of total thyroidectomy on thyroid function.
METHODS
Monocentric observational prospective study. Patients who benefited from a total thyroidectomy in the Department of Otolaryngology-Head and Neck Surgery between September 2017 and July 2019 were included. Three blood samples were taken from each patient during the perioperative period: preoperatively (T), intraoperatively (T), and postoperatively (T). Changes in TSH, T4, T3, and thyroglobulin levels were evaluated from T to T. Epidemiological data were retrieved from the medical charts. Statistical analyses were performed for the entire cohort and subgroups regarding preoperative treatment and type of disease.
RESULTS
Seventy-seven patients were included in the study. T4 and thyroglobulin levels increased significantly from T to T. TSH, T4, T3, and thyroglobulin levels decreased significantly from T to T.
CONCLUSIONS
Our study confirmed the hypothesis of variable kinetics of thyroid hormone levels associated with the manipulation of the thyroid gland during surgery, but none of these changes resulted in clinical effects, including thyrotoxicosis.
引言
评估全甲状腺切除术对甲状腺功能的影响。
方法
单中心观察性前瞻性研究。纳入2017年9月至2019年7月在耳鼻咽喉-头颈外科接受全甲状腺切除术的患者。在围手术期从每位患者采集三份血样：术前（T）、术中（T）和术后（T）。评估从T到T促甲状腺激素（TSH）、甲状腺素（T4）、三碘甲状腺原氨酸（T3）和甲状腺球蛋白水平的变化。从病历中获取流行病学数据。对整个队列以及术前治疗和疾病类型的亚组进行统计分析。
结果
77例患者纳入研究。从T到T，T4和甲状腺球蛋白水平显著升高。从T到T，TSH、T4、T3和甲状腺球蛋白水平显著降低。
结论
我们的研究证实了与手术中甲状腺操作相关的甲状腺激素水平变化动力学的假设，但这些变化均未产生临床影响，包括甲状腺毒症。
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