Talens Amparo, López-Pintor Elsa, Bejerano Marta, Guilabert Mercedes, Aznar María Teresa, Aznar-Lou Ignacio, Lumbreras Blanca
Servicio de Farmacia, Hospital General Universitario de Elda, 03600 Alicante, Spain.
Departamento de Ingeniería, Área de Farmacia y Tecnología Farmacéutica, Universidad Miguel Hernández, 03550 Alicante, Spain.
J Clin Med. 2022 Apr 26;11(9):2436. doi: 10.3390/jcm11092436.
Background: Several factors can influence adherence to orally administered antineoplastics, including fear or anxiety resulting from situations such as the COVID-19 pandemic. The aim of this study was to analyse the influence of these patients’ experiences on adherence to orally administered antineoplastics. Methods: Cross-sectional study in four hospitals including >18 year old cancer patients receiving orally administered antineoplastics during the first half of 2021. Data were collected from medical records and through telephone interviews. Adherence was assessed through the prescription refill records and pill counts. Patients’ fear resulting from the pandemic was assessed by means of a structured questionnaire using a 5-point Likert-type scale. Results: Our sample compr BARCELONAised 268 patients (54% men) with a mean age of 64 years (SD 12). More than 15% had experienced afraid and 5% had experienced a dangerous situation when attending hospital, 17% felt they had received less care, and 30% preferred telepharmacy. Adherence measured by pill count was 69.3% and 95.5% according to prescription refill records. Patients who had experienced fear or anxiety when attending hospital were less adherent (aOR 0.47, 95% CI 0.23−0.96, p = 0.039). Conclusion: The fear experienced by some patients has affected adherence to treatment.
多种因素会影响口服抗肿瘤药的依从性，包括新冠疫情等情况引发的恐惧或焦虑。本研究旨在分析这些患者的经历对口服抗肿瘤药依从性的影响。方法：在四家医院开展横断面研究，纳入2021年上半年接受口服抗肿瘤药治疗的18岁以上癌症患者。数据从病历中收集，并通过电话访谈获取。通过处方 refill 记录和药丸计数评估依从性。采用5点李克特量表通过结构化问卷评估患者因疫情产生的恐惧。结果：我们的样本包括268名患者（54%为男性），平均年龄64岁（标准差12）。超过15%的患者在就医时经历过恐惧，5%经历过危险情况，17%觉得得到的护理较少，30%更喜欢远程药房。根据处方 refill 记录，通过药丸计数测得的依从性为69.3%，根据处方 refill 记录为95.5%。在就医时经历过恐惧或焦虑的患者依从性较低（调整后比值比0.47，95%置信区间0.23−0.96，p = 0.039）。结论：部分患者经历的恐惧影响了治疗依从性。
