视网膜血管炎：动物与人类疾病的相关性

Retinal vasculitis: correlation of animal and human disease.

作者信息

Stanford M R, Graham E M, Kasp E, Brown E C, Dumonde D C, Sanders M D

出版信息

Eye (Lond). 1987;1 ( Pt 1):69-77. doi: 10.1038/eye.1987.11.

DOI:10.1038/eye.1987.11

Abstract

A form of experimental retinal vasculitis was induced in black hooded Lister rats by the inoculation of retinal S-antigen. Comparison of this disease with retinal vasculitis in man showed striking clinical, angiographic and pathological similarities. Clinically disc oedema, periphlebitis and retinal infiltrates were observed with corresponding leakage of dye on fluorescein angiography. Pathologically the disease showed perivascular lymphocytic infiltrates with focal photoreceptor necrosis. These characteristic features make this an ideal model for the study of the pathogenesis of retinal vasculitis in man.

摘要

通过接种视网膜S抗原，在黑色帽状利斯特大鼠中诱发了一种实验性视网膜血管炎。将这种疾病与人类视网膜血管炎进行比较，发现临床、血管造影和病理方面存在显著相似之处。临床上观察到视盘水肿、静脉周围炎和视网膜浸润，荧光素血管造影显示相应的染料渗漏。病理上，该病表现为血管周围淋巴细胞浸润伴局灶性光感受器坏死。这些特征使其成为研究人类视网膜血管炎发病机制的理想模型。