Hwang Joo-Hee, Hwang Jeong-Hwan, Lee Seung Yeob, Lee Jaehyeon
Department of Internal Medicine, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Korea.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea.
J Clin Med. 2022 Apr 29;11(9):2521. doi: 10.3390/jcm11092521.
Hypervirulent (hvKp) is an important strain that can cause multiple organ infections. Although hvKp infection cases are increasing, there is limited information on the prostatic abscesses caused by . Furthermore, the clinical significance of hvKp associated with K1 or K2 capsular types or virulence genes in prostatic abscesses remains unclear. Therefore, we aimed to elucidate the clinical and microbiological characteristics of prostatic abscesses caused by in relation to various virulence genes. A retrospective study was performed at a 1200-bed tertiary hospital between January 2014 and December 2019. Patients diagnosed with prostatic abscesses with isolated from blood, urine, pus, or tissue cultures were enrolled in this study. Our results demonstrate that 30.3% (10/33) of the prostatic abscesses were caused by . All strains isolated from patients with prostatic abscesses due to were the K1 capsular type, and eight patients (80.0%) carried and genes that identified hvKp. These findings suggest that hvKp is an important pathogen in prostatic abscesses. Therefore, when treating patients with prostatic abscesses, attention should be paid to the characteristics of hvKp, such as bacteremia, multiorgan abscess formation, and metastatic spread.
高毒力肺炎克雷伯菌(hvKp)是一种可导致多器官感染的重要菌株。尽管hvKp感染病例在增加,但关于其所致前列腺脓肿的信息有限。此外,与K1或K2荚膜型或毒力基因相关的hvKp在前列腺脓肿中的临床意义仍不清楚。因此,我们旨在阐明由hvKp引起的前列腺脓肿与各种毒力基因相关的临床和微生物学特征。在一家拥有1200张床位的三级医院于2014年1月至2019年12月进行了一项回顾性研究。本研究纳入了从血液、尿液、脓液或组织培养物中分离出hvKp且被诊断为前列腺脓肿的患者。我们的结果表明,30.3%(10/33)的前列腺脓肿由hvKp引起。从因hvKp导致前列腺脓肿的患者中分离出的所有菌株均为K1荚膜型,并且8名患者(80.0%)携带可鉴定hvKp的rmpA和rmpA2基因。这些发现表明hvKp是前列腺脓肿中的一种重要病原体。因此,在治疗hvKp所致前列腺脓肿的患者时,应注意hvKp的特征,如菌血症、多器官脓肿形成和转移性扩散。