Kim Mihui, Yang Yong Sook, Ko Young-Guk, Choi Mona
College of Nursing, Brain Korea 21 FOUR Project, Yonsei University, Seoul 03722, Korea.
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
J Clin Med. 2022 May 1;11(9):2547. doi: 10.3390/jcm11092547.
For peripheral artery disease (PAD) patients, after endovascular revascularization, it is crucial to manage associated factors that can affect the risk of major adverse events. We aimed to investigate the associated factors of major adverse events in these patients.
We conducted a retrospective longitudinal analysis using the electronic medical records from a tertiary hospital in Korea and included the data of 1263 patients. Eligible patients were categorized into four groups based on diabetes mellitus (DM) and regular exercise. The major adverse events included major adverse limb events and major adverse cardiovascular events. Major adverse events-free survival was assessed using the Kaplan-Meier method, and associated factors of major adverse events were analyzed using Cox proportional hazards analyses.
Kaplan-Meier survival curves showed that patients with DM and non-regular exercise had a shorter major adverse events-free survival. The Cox regression analysis showed that for patients with critical limb ischemia or chronic kidney disease, the risk of major adverse events increased, while group variables were not significant.
Target management of patients with DM, critical limb ischemia, and chronic kidney disease is essential to reduce major adverse events after endovascular revascularization in patients with PAD.
对于外周动脉疾病（PAD）患者，血管内血运重建术后，控制可能影响主要不良事件风险的相关因素至关重要。我们旨在调查这些患者主要不良事件的相关因素。
我们使用韩国一家三级医院的电子病历进行了一项回顾性纵向分析，纳入了1263例患者的数据。符合条件的患者根据糖尿病（DM）和规律运动分为四组。主要不良事件包括主要肢体不良事件和主要心血管不良事件。采用Kaplan-Meier法评估无主要不良事件生存率，并使用Cox比例风险分析来分析主要不良事件的相关因素。
Kaplan-Meier生存曲线显示，患有糖尿病且不经常运动的患者无主要不良事件生存期较短。Cox回归分析显示，对于严重肢体缺血或慢性肾脏病患者，主要不良事件风险增加，而分组变量无显著意义。
对糖尿病、严重肢体缺血和慢性肾脏病患者进行目标管理，对于降低PAD患者血管内血运重建术后的主要不良事件至关重要。
