补充维生素D对合并早期胎儿生长受限的妊娠期脑胎盘比率的影响。

Effect of Vitamin D Supplementation on the Cerebral Placental Ratio in Pregnancy Complicated with Early Fetal Growth Restriction.

作者信息

Jakubiec-Wisniewska Karolina, Huras Hubert, Kolak Magdalena

机构信息

Department of Obstetrics and Perinatology, Jagiellonian University Medical College, 31-501 Krakow, Poland.

出版信息

J Clin Med. 2022 May 7;11(9):2627. doi: 10.3390/jcm11092627.

DOI:10.3390/jcm11092627

PMID:35566753

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9101193/

Abstract

Fetal growth restriction (FGR) is a complication of pregnancy connected with increased risk of intrauterine fetal demise. To increase the diagnostic accuracy, the cerebral placental ratio (CPR) is used. Vitamin D may play a role in the regulation of vascular flow in the fetus. The aim is to assess the relationship between CPR and vitamin D supplementation in fetuses with early FGR. It is a prospective cohort study. Pregnant females were divided into groups with 2000 IU and <500 IU of vitamin D. Both groups were observed for 14 days; USG was performed three times with one-week intervals. EFW and CPR were measured. Absolute CPR values were initially observed to differ significantly (p = 0.0032). Measurements on the seventh day of observation indicated that CPR was significantly higher (p = 0.0455) in fetuses of patients receiving vitamin D at a dose of 2000 IU 1.75 (IQR: 1.47; 2.06) vs. <500 IU group 1.55 (IQR: 1.04; 1.52). Similarly, on day 14: (p < 0.0001)—2.39 (IQR: 1.82; 2.69) vs. 1.21 (IQR: 0.98; 1.52). Supplementation with vitamin D at a dose of 2000 IU may have an influence on the increase in the CPR in fetuses with early FGR.

摘要

胎儿生长受限（FGR）是一种与宫内胎儿死亡风险增加相关的妊娠并发症。为提高诊断准确性，采用了脑胎盘比率（CPR）。维生素D可能在胎儿血管血流调节中发挥作用。目的是评估早期FGR胎儿中CPR与维生素D补充之间的关系。这是一项前瞻性队列研究。将怀孕女性分为维生素D剂量为2000 IU和<500 IU的组。两组均观察14天；超声检查（USG）每隔一周进行三次。测量估计胎儿体重（EFW）和CPR。最初观察到绝对CPR值有显著差异（p = 0.0032）。观察第7天的测量结果表明，接受2000 IU维生素D的患者胎儿的CPR显著更高（p = 0.0455），为1.75（四分位间距：1.47；2.06），而<500 IU组为1.55（四分位间距：1.04；1.52）。同样，在第14天：（p < 0.0001）——2.39（四分位间距：1.82；2.69）对比1.21（四分位间距：0.98；1.52）。补充2000 IU剂量的维生素D可能会影响早期FGR胎儿CPR的增加。