Tan Rachel Yie Hang, Lee Choy Sin, Pichika Mallikarjuna Rao, Cheng Sit Foon, Lam Ki Yan
School of Postgraduate, International Medical University, Kuala Lumpur 57000, Malaysia.
Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia.
Polymers (Basel). 2022 Apr 20;14(9):1672. doi: 10.3390/polym14091672.
Due to the specific physiological pH throughout the human body, pH-responsive polymers have been considered for aiding drug delivery systems. Depending on the surrounding pH conditions, the polymers can undergo swelling or contraction behaviors, and a degradation mechanism can release incorporated substances. Additionally, polyurethane, a highly versatile polymer, has been reported for its biocompatibility properties, in which it demonstrates good biological response and sustainability in biomedical applications. In this review, we focus on summarizing the applications of pH-responsive polyurethane in the biomedical and drug delivery fields in recent years. In recent studies, there have been great developments in pH-responsive polyurethanes used as controlled drug delivery systems for oral administration, intravaginal administration, and targeted drug delivery systems for chemotherapy treatment. Other applications such as surface biomaterials, sensors, and optical imaging probes are also discussed in this review.
由于人体全身特定的生理pH值，pH响应性聚合物已被考虑用于辅助药物递送系统。根据周围的pH条件，聚合物可以发生溶胀或收缩行为，并且一种降解机制可以释放所包封的物质。此外，聚氨酯是一种用途广泛的聚合物，据报道具有生物相容性，在生物医学应用中表现出良好的生物学反应和可持续性。在本综述中，我们重点总结了近年来pH响应性聚氨酯在生物医学和药物递送领域的应用。在最近的研究中，用作口服给药、阴道内给药的控释药物递送系统以及化疗治疗的靶向药物递送系统的pH响应性聚氨酯有了很大的发展。本综述还讨论了其他应用，如表面生物材料、传感器和光学成像探针。
