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促进毛发再生:通过表面修饰策略定制纳米结构脂质载体的最新进展。

Enhancing hair regeneration: Recent progress in tailoring nanostructured lipid carriers through surface modification strategies.

作者信息

Atrooz Omar M, Reihani Nasim, Mozafari M R, Salawi Ahmad, Taghavi Elham

机构信息

Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.

Department of Biological Sciences, Mutah University, Mutah, Jordan.

出版信息

ADMET DMPK. 2024 Jul 20;12(3):431-462. doi: 10.5599/admet.2376. eCollection 2024.

Abstract

BACKGROUND AND PURPOSE

Hair loss is a prevalent problem affecting millions of people worldwide, necessitating innovative and efficient regrowth approaches. Nanostructured lipid carriers (NLCs) have become a hopeful option for transporting bioactive substances to hair follicles because of their compatibility with the body and capability to improve drug absorption.

REVIEW APPROACH

Recently, surface modification techniques have been used to enhance hair regeneration by improving the customization of NLCs. These techniques involve applying polymers, incorporating targeting molecules, and modifying the surface charge.

KEY RESULTS

The conversation focuses on how these techniques enhance stability, compatibility with the body, and precise delivery to hair follicles within NLCs. Moreover, it explains how surface-modified NLCs can improve the bioavailability of hair growth-promoting agents like minoxidil and finasteride. Furthermore, information on how surface-modified NLCs interact with hair follicles is given, uncovering their possible uses in treating hair loss conditions.

CONCLUSION

This review discusses the potential of altering the surface of NLCs to customize them for enhanced hair growth. It offers important information for upcoming studies on hair growth.

摘要

背景与目的

脱发是一个普遍存在的问题,影响着全球数百万人,因此需要创新且高效的生发方法。纳米结构脂质载体(NLCs)因其与人体的相容性以及改善药物吸收的能力,已成为将生物活性物质输送至毛囊的一个有希望的选择。

综述方法

最近,表面修饰技术已被用于通过改进NLCs的定制来促进头发生长。这些技术包括应用聚合物、掺入靶向分子以及修饰表面电荷。

关键结果

讨论集中于这些技术如何增强NLCs的稳定性、与人体的相容性以及向毛囊的精准递送。此外,还解释了表面修饰的NLCs如何提高米诺地尔和非那雄胺等促发生长剂的生物利用度。此外,还给出了关于表面修饰的NLCs如何与毛囊相互作用的信息,揭示了它们在治疗脱发病症中的潜在用途。

结论

本综述讨论了改变NLCs表面以使其定制化以促进头发生长的潜力。它为即将开展的头发生长研究提供了重要信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/355b/11289513/7bf9ae234bd0/ADMET-12-2376-g001.jpg

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