Rheumatology Clinic, Dipartimento Di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ospedale "Carlo Urbani", Jesi (Ancona), Italy.
Dipartimento di Scienze Radiologiche, Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy.
Radiol Med. 2022 Jun;127(6):652-663. doi: 10.1007/s11547-022-01499-0. Epub 2022 May 14.
The goal of this study is to investigate the relationship between joint inflammation and damage of the wrists and hands, measured by semiquantitative ultrasound and magnetic resonance imaging scoring systems, with functional disability and handgrip strength (HGs).
Consecutive adult RA patients with active disease, as defined by a Disease Activity Score 28 joints C-reactive protein (DAS28-CRP) > 3.2, underwent a cross-sectional evaluation comprehensive of a clinimetric assessment, an HGs evaluation, an ultrasound assessment aimed at calculating the UltraSound-CLinical ARthritis Activity (US-CLARA), and a magnetic resonance imaging scored according to the modified Simplified Rheumatoid Arthritis Magnetic Resonance Imaging Score (mod SAMIS). The Spearman's rho correlation coefficient was used to test the correlations.
Sixty-six patients with RA were investigated (age 55.6 ± 12.2 years). The mod SAMIS total score and the US-CLARA had a weak but significant correlation (rho = 0.377, p = 0.0018). Among the mod SAMIS sub-scores, there was a significant relationship between mod SAMIS bone edema (SAMIS-BME) and US-CLARA (rho = 0.799, p < 0.001) and mod SAMIS synovitis (SAMIS synovitis) and US-CLARA (rho = 0.539, p < 0.001). There were also significant negative relationships between the HGs score and the mod SAMIS total score and US-CLARA (rho = - 0.309, p = 0.011 and rho = - 0.775, p < 0.0001, respectively).
BME and synovitis have an influence on the function of the upper extremities. The US-CLARA and the mod SAMIS total score are intriguing options for semiquantitative assessment of joint inflammation and damage in RA.
本研究旨在探讨腕关节和手部的关节炎症和损伤与功能障碍和手握力（HG）之间的关系，这些损伤通过半定量超声和磁共振成像评分系统进行测量。
连续的患有活动性疾病的成年 RA 患者，其疾病活动评分 28 个关节 C 反应蛋白（DAS28-CRP）>3.2，进行了横断面评估，包括临床计量学评估、HG 评估、旨在计算超声临床关节炎活动（US-CLARA）的超声评估，以及根据改良简化类风湿关节炎磁共振成像评分（mod SAMIS）进行的磁共振成像评分。采用 Spearman rho 相关系数检验相关性。
共调查了 66 例 RA 患者（年龄 55.6±12.2 岁）。mod SAMIS 总分和 US-CLARA 之间存在弱但显著的相关性（rho=0.377，p=0.0018）。在 mod SAMIS 子评分中，mod SAMIS 骨水肿（SAMIS-BME）与 US-CLARA 之间存在显著关系（rho=0.799，p<0.001），mod SAMIS 滑膜炎与 US-CLARA 之间也存在显著关系（rho=0.539，p<0.001）。HG 评分与 mod SAMIS 总分和 US-CLARA 之间也存在显著负相关（rho=-0.309，p=0.011 和 rho=-0.775，p<0.0001）。
BME 和滑膜炎对上肢功能有影响。US-CLARA 和 mod SAMIS 总分是 RA 关节炎症和损伤半定量评估的有趣选择。
