Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands; Department of Anatomy & Embryology, Maastricht University, Maastricht, The Netherlands.
Biochem Pharmacol. 2022 Jul;201:115074. doi: 10.1016/j.bcp.2022.115074. Epub 2022 May 11.
The liver controls the systemic exposure of amino acids entering via the gastro-intestinal tract. For most amino acids except branched chain amino acids, hepatic uptake is very efficient. This implies that the liver orchestrates amino acid metabolism and also controls systemic amino acid exposure. Although many amino acid transporters have been identified, cloned and investigated with respect to substrate specificity, transport mechanism, and zonal distribution, which of these players are involved in hepatocellular amino acid transport remains unclear. Here, we aim to provide a review of current insight into the molecular machinery of hepatic amino acid transport. Furthermore, we place this information in a comprehensive overview of amino acid transport, signalling and metabolism.
肝脏控制着通过胃肠道进入的氨基酸的全身暴露。对于除支链氨基酸以外的大多数氨基酸，肝脏摄取非常有效。这意味着肝脏协调氨基酸代谢，也控制全身氨基酸暴露。尽管已经鉴定、克隆了许多氨基酸转运体，并针对其底物特异性、转运机制和区域分布进行了研究，但哪些转运体参与肝细胞氨基酸转运仍不清楚。在这里，我们旨在对肝脏氨基酸转运的分子机制的最新认识进行综述。此外，我们还将这些信息置于氨基酸转运、信号转导和代谢的全面概述中。
