Wolford S T, Schroer R A, Gallo P P, Gohs F X, Brodeck M, Falk H B, Ruhren R
Fundam Appl Toxicol. 1987 Jan;8(1):80-8. doi: 10.1016/0272-0590(87)90102-3.
Age-related changes in serum chemistry and hematology values in male and female Sprague-Dawley rats 2 to 29 months of age are described. The number of values per determination (N) ranged from 554 to 1126. Serum chemistry parameters demonstrating changes with time included inorganic phosphorus, total protein, cholesterol, triglycerides, and alkaline phosphatase. There was little or no sex difference among these parameters. Hematologic parameters demonstrating changes with time included leukocyte elements (lymphocytes, neutrophils, eosinophils, monocytes), erythrocyte parameters (red blood cell count, hematocrit, hemoglobin, mean cell volume, mean cell hemoglobin), and platelet count. Most trends in erythrocyte parameters were more marked in males than in females. To visualize the effect of age of these parameters, the data were plotted vs time, and fitted models were superimposed on the graphs. Comparisons with available literature values are made, and the value of an age-related data base when conducting long-term toxicity studies is discussed.
描述了2至29月龄雄性和雌性斯普拉格-道利大鼠血清化学和血液学值的年龄相关变化。每次测定的值数量（N）范围为554至1126。随时间变化的血清化学参数包括无机磷、总蛋白、胆固醇、甘油三酯和碱性磷酸酶。这些参数之间几乎没有性别差异。随时间变化的血液学参数包括白细胞成分（淋巴细胞、中性粒细胞、嗜酸性粒细胞、单核细胞）、红细胞参数（红细胞计数、血细胞比容、血红蛋白、平均细胞体积、平均细胞血红蛋白）和血小板计数。红细胞参数的大多数趋势在雄性中比在雌性中更明显。为了直观显示年龄对这些参数的影响，将数据与时间作图，并将拟合模型叠加在图上。与现有文献值进行了比较，并讨论了在进行长期毒性研究时年龄相关数据库的价值。
