Scortichini B H, Quast J F, Rao K S
Fundam Appl Toxicol. 1987 Feb;8(2):272-9. doi: 10.1016/0272-0590(87)90126-6.
2-Phenoxyethanol was applied to the clipped skin of pregnant rabbits on Days 6 through 18 of gestation in order to assess the fetotoxic and teratogenic potential by the dermal route. Rabbits were treated with 0, 300, 600, or 1000 mg/kg/day of 2-phenoxyethanol, and fetuses were examined for external, visceral, and skeletal alterations. Dermal application of 1000 mg/kg/day produced maternal toxicity as evidenced by intravascular hemolysis of red blood cells and death in some animals. Maternal toxicity was observed in rabbits treated with 600 mg 2-phenoxyethanol/kg/day but at a lower incidence than that observed at 1000 mg/kg/day. Nine rabbits in the 1000 mg/kg/day dose group and five rabbits at 600 mg/kg/day died or were sacrificed in extremis. Rabbits in the two highest dose groups which survived until Day 28 of gestation showed no evidence of treatment-related effects. No signs of maternal toxicity were seen at 300 mg/kg/day. Examination of rabbit fetuses indicated that, at the dosages tested, 2-phenoxyethanol was not embryotoxic, fetotoxic, or teratogenic.
为了通过皮肤途径评估2-苯氧乙醇的胚胎毒性和致畸潜力，在妊娠第6天至18天，将其涂抹于怀孕兔子的剪毛皮肤上。给兔子分别用0、300、600或1000mg/kg/天的2-苯氧乙醇进行处理，并检查胎儿的外部、内脏和骨骼变化。每天经皮肤给予1000mg/kg可产生母体毒性，表现为一些动物出现红细胞血管内溶血和死亡。在给予600mg 2-苯氧乙醇/kg/天的兔子中观察到母体毒性，但发生率低于1000mg/kg/天组。1000mg/kg/天剂量组中有9只兔子以及600mg/kg/天组中有5只兔子死亡或濒死时被处死。存活至妊娠第28天的两个最高剂量组兔子未表现出与处理相关的效应迹象。300mg/kg/天未观察到母体毒性迹象。对兔子胎儿的检查表明，在所测试的剂量下，2-苯氧乙醇没有胚胎毒性、胎儿毒性或致畸性。
