Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Int Wound J. 2010 Feb;7(1):62-9. doi: 10.1111/j.1742-481X.2009.00648.x.
A combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) is a commonly used disinfectant in human medicine. As porcine skin represents an adequate model for human skin, the effect of octenidine dihydrochloride and phenoxyethanol on wound healing is studied in pigs. Furthermore, the in vitro percutaneous permeation of the test substances is studied. The impact of the test formulations on wound healing is examined (A) under non occlusive conditions and (B) in comparison to another disinfectant based on povidone-iodine under occlusive conditions, while wounds are treated daily with the test substances. The percutaneous permeation of octenidine dihydrochloride and phenoxyethanol is studied in Franz-type diffusion cells with intact skin as well as barrier disrupted after tape stripping. Compared with povidone-iodine or vehicle treatment as well as untreated control wounds the treatment of wounds with the test formulation has no influence on the healing rate in pigs and does not induce retardation of wound healing. The in vitro diffusion experiment reveals that octenidine dihydrochloride is only detectable in the acceptor chamber of three-barrier disrupted skin samples. Phenoxyethanol permeates through intact porcine skin in amounts of 11.3% and through barrier disrupted skin in amounts of 43.9%
0.1% 盐酸奥替尼啶和 2% 2-苯氧乙醇（奥替尼啶）的组合是一种常用于人类医学的消毒剂。由于猪皮是人类皮肤的良好模型，因此研究了盐酸奥替尼啶和苯氧乙醇对猪伤口愈合的影响。此外，还研究了测试物质的体外经皮渗透。检查了测试配方对伤口愈合的影响（A）在非闭塞条件下和（B）与另一种基于聚维酮碘的消毒剂在闭塞条件下进行比较，同时每天用测试物质处理伤口。使用 Franz 型扩散池研究了盐酸奥替尼啶和苯氧乙醇在完整皮肤和经胶带剥离破坏屏障后的经皮渗透。与聚维酮碘或载体处理以及未处理的对照伤口相比，用测试制剂处理伤口对猪的愈合率没有影响，也不会延迟伤口愈合。体外扩散实验表明，盐酸奥替尼啶仅在三屏障破坏皮肤样本的接受室中可检测到。苯氧乙醇通过完整的猪皮渗透的量为 11.3%，通过破坏屏障的皮肤渗透的量为 43.9%。
