日本一株罕见 G9P[4]型 A 轮状病毒的全基因组序列，其含有 DS-1 样（基因型 2）基因。
Whole genome sequence of an uncommon G9P[4] species A rotavirus containing DS-1-like (genotype 2) genes in Japan.
机构信息
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
出版信息
Arch Virol. 2022 Jul;167(7):1603-1606. doi: 10.1007/s00705-022-05462-2. Epub 2022 May 14.
Species A rotaviruses (RVAs) have been recognized as one of the leading causes of acute gastroenteritis in humans worldwide. Here, the complete coding sequences of 11 RNA segments of an uncommon G9P[4] RVA strain, which was detected in feces of a diarrheal child in Japan, were determined by next-generation sequencing technology. Its genomic constellation, VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5, was determined as G9-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2. This work reports the complete coding sequences of a G9P[4] RVA strain containing DS-1-like (genotype 2) genes that was isolated in Japan in 2013.
A 型轮状病毒（RVAs）已被确认为全球范围内导致人类急性肠胃炎的主要病原体之一。本研究通过下一代测序技术，确定了一株在日本腹泻患儿粪便中检测到的罕见 G9P[4]RVA 毒株的 11 个 RNA 片段的完整编码序列。其基因组结构为 VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5，由 G9-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 组成。本研究报告了一株 2013 年在日本分离的含有 DS-1 样（基因型 2）基因的 G9P[4]RVA 毒株的完整编码序列。
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