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Surveillance of Injury Types, Locations, and Intensities in Male and Female Tennis Players: A Content Analysis of Online Newspaper Reports.男性和女性网球运动员损伤类型、部位和严重程度的监测：对在线报纸报道的内容分析。
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Mechanisms Involved in Microglial-Interceded Alzheimer's Disease and Nanocarrier-Based Treatment Approaches.小胶质细胞介导的阿尔茨海默病相关机制及基于纳米载体的治疗方法
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Pharmacological and Epigenetic Regulators of NLRP3 Inflammasome Activation in Alzheimer's Disease.阿尔茨海默病中NLRP3炎性小体激活的药理学和表观遗传学调节因子
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Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer's Disease.解析脑淀粉样血管病和阿尔茨海默病中内皮线粒体损伤、血管炎症和神经退行性变的串扰。
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The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense.绿茶对大鼠睡眠剥夺诱导的认知缺陷的有益作用：海马抗氧化防御的参与
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Effect of chronic sleep deprivation and sleep recovery on hippocampal CA3 neurons, spatial memory and anxiety-like behavior in rats.慢性睡眠剥夺及睡眠恢复对大鼠海马 CA3 神经元、空间记忆及焦虑样行为的影响。
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The role of pathological tau in synaptic dysfunction in Alzheimer's diseases.病理性 tau 在阿尔茨海默病中突触功能障碍的作用。
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睡眠障碍对阿尔茨海默病有双重影响吗？

Do Sleep Disturbances have a Dual Effect on Alzheimer's Disease?

作者信息

Arjmandi-Rad Shirin, Ebrahimnejad Mahshid, Zarrindast Mohammad-Reza, Vaseghi Salar

机构信息

Institute for Cognitive & Brain Sciences, Shahid Beheshti University, Tehran, Iran.

Department of Physiology, Faculty of Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.

出版信息

Cell Mol Neurobiol. 2023 Mar;43(2):711-727. doi: 10.1007/s10571-022-01228-1. Epub 2022 May 14.

DOI:10.1007/s10571-022-01228-1
PMID:35568778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11415194/
Abstract

Sleep disturbances and Alzheimer's disease have deleterious effects on various physiological and cognitive functions including synaptic plasticity, oxidative stress, neuroinflammation, and memory. In addition, clock genes expression is significantly altered following sleep disturbances, which may be involved in the pathogenesis of Alzheimer's disease. In this review article, we aimed to discuss the role of sleep disturbances and Alzheimer's disease in the regulation of synaptic plasticity, oxidative stress, neuroinflammation, and clock genes expression. Also, we aimed to find significant relationships between sleep disturbances and Alzheimer's disease in the modulation of these mechanisms. We referred to the controversial effects of sleep disturbances (particularly those related to the duration of sleep deprivation) on the modulation of synaptic function and neuroinflammation. We aimed to know that, do sleep disturbances have a dual effect on the progression of Alzheimer's disease? Although numerous studies have discussed the association between sleep disturbances and Alzheimer's disease, the new point of this study was to focus on the controversial effects of sleep disturbances on different biological functions, and to evaluate the potential dualistic role of sleep disturbances in the pathogenesis of Alzheimer's disease.

摘要

睡眠障碍和阿尔茨海默病对包括突触可塑性、氧化应激、神经炎症和记忆在内的各种生理和认知功能具有有害影响。此外，睡眠障碍后生物钟基因表达会发生显著改变，这可能与阿尔茨海默病的发病机制有关。在这篇综述文章中，我们旨在探讨睡眠障碍和阿尔茨海默病在调节突触可塑性、氧化应激、神经炎症和生物钟基因表达方面的作用。此外，我们旨在找出睡眠障碍和阿尔茨海默病在这些机制调节中的显著关系。我们提到了睡眠障碍（特别是与睡眠剥夺持续时间相关的睡眠障碍）对突触功能和神经炎症调节的争议性影响。我们旨在了解，睡眠障碍对阿尔茨海默病的进展是否具有双重作用？尽管众多研究已经讨论了睡眠障碍与阿尔茨海默病之间的关联，但本研究的新要点在于关注睡眠障碍对不同生物学功能的争议性影响，并评估睡眠障碍在阿尔茨海默病发病机制中的潜在双重作用。