Joint Research Team from Japanese Society of Nephrology and the Progressive Renal Diseases Research, Research on Intractable Disease, from the Ministry of Health, Labour and Welfare of Japan, Special Study Group for Nephrotic Syndrome, Tokyo, Japan.
Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Japan.
Clin Exp Nephrol. 2022 Sep;26(9):909-916. doi: 10.1007/s10157-022-02231-y. Epub 2022 May 15.
Recent clinical reports indicate a correlation between new-onset and relapse of nephrotic syndrome (NS) following coronavirus 2019 (COVID-19) vaccination in patients with glomerular diseases. However, there are no reports of a nationwide survey on NS following COVID-19 vaccination in Japan.
We conducted a web-based survey of council members of the Japanese Society of Nephrology (581 members, 382 facilities) to elucidate the relationship between COVID-19 vaccination and new-onset and relapse of NS.
Following COVID-19 vaccination, 27 patients (male: 15, 55.6%) with new-onset (n = 6) and relapse (n = 21) of NS were reported. Of them, 12 (44.4%) patients were diagnosed with minimal change disease at the occurrence of NS. Five patients developed a slight increase in serum creatinine levels; however, none progressed to severe renal dysfunction.
Our findings clarify the clinical features of new-onset and relapse of NS following COVID-19 vaccination. Although there was no obvious progression to severe renal dysfunction, clinicians and pathologists should be aware that NS is a potential adverse effect of the vaccines.
最近的临床报告表明，在肾小球疾病患者中，新冠病毒 2019（COVID-19）疫苗接种后会出现新发和复发肾病综合征（NS）。然而，目前尚无关于日本 COVID-19 疫苗接种后 NS 的全国性调查报道。
我们对日本肾脏病学会的理事会成员（581 名成员，382 个机构）进行了一项基于网络的调查，以阐明 COVID-19 疫苗接种与新发和复发 NS 之间的关系。
COVID-19 疫苗接种后，有 27 例（男性 15 例，55.6%）新发（n=6）和复发（n=21）NS 的患者报告。其中，12 例（44.4%）患者在发生 NS 时被诊断为微小病变病。5 例患者的血清肌酐水平略有升高；但均未进展为严重肾功能不全。
我们的研究结果阐明了 COVID-19 疫苗接种后新发和复发 NS 的临床特征。虽然没有明显进展为严重肾功能不全，但临床医生和病理学家应意识到 NS 是疫苗的潜在不良反应。
