递归分区法确定头颈部皮肤鳞状细胞癌区域转移特征的显著性顺序。
Recursive Partitioning to Determine Order of Significance of Regional Metastasis Characteristics in Head and Neck Cutaneous Squamous Cell Carcinoma.
机构信息
Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, NSW, Australia.
National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
出版信息
Ann Surg Oncol. 2022 Oct;29(11):6991-6999. doi: 10.1245/s10434-022-11863-z. Epub 2022 May 15.
BACKGROUND
The order of significance of clinicopathologic characteristics for the prognosis of patients with regional metastases from head and neck cutaneous squamous cell carcinoma (HNcSCC) is not well characterized. This study aimed to understand the impact of the known characteristics, including the presence of immunosuppression, number of deposits, largest deposit size, location and laterality of deposits, and presence of extranodal extension (ENE) on overall survival (OS) and disease-specific survival (DSS).
METHODS
A retrospective study of 366 patients treated with curative intent for HNcSCC with regional metastatic disease was undertaken using recursive partitioning analysis (RPA).
RESULTS
Using RPA modeling, the study determined that number of metastatic deposits carried the highest impact for both OS and DSS, followed by largest deposit size. The presence of ENE and immunosuppression was less significant.
CONCLUSIONS
The results from this study provide new evidence for identifying and stratifying high-risk patients with metastatic HNcSCC. This information will be valuable in determining future HNcSCC staging systems.
背景
头颈部皮肤鳞状细胞癌（HNcSCC）区域转移患者的预后与临床病理特征的重要性顺序尚未得到很好的描述。本研究旨在了解已知特征（包括免疫抑制的存在、转移灶数量、最大转移灶大小、转移灶位置和侧别以及是否存在结外扩展（ENE））对总生存（OS）和疾病特异性生存（DSS）的影响。
方法
采用递归分区分析（RPA）对 366 例接受根治性治疗的 HNcSCC 伴区域转移疾病的患者进行回顾性研究。
结果
使用 RPA 模型，研究确定转移灶数量对 OS 和 DSS 的影响最大，其次是最大转移灶大小。ENE 和免疫抑制的存在影响较小。
结论
本研究的结果为识别和分层高危转移性 HNcSCC 患者提供了新的证据。这些信息对于确定未来的 HNcSCC 分期系统将非常有价值。
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