State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Aug 30;118:110574. doi: 10.1016/j.pnpbp.2022.110574. Epub 2022 May 13.
Abnormal interactions among addiction brain networks associated with intoxication, negative affect, and anticipation may have relevance for internet gaming disorder (IGD). Despite prior studies having identified gender-related differences in the neural correlates of IGD, gender-related differences in the involvement of brain networks remain unclear.
One-hundred-and-nine individuals with IGD (54 males) and 111 with recreational game use (RGU; 58 males) provided resting-state fMRI data. We examined gender-related differences in involvement of addiction brain networks in IGD versus RGU subjects. We further compared the strength between and within addiction brain networks and explored possible relationships between the strength of functional connectivities within and between addiction brain networks and several relevant behavioral measures.
The addiction brain networks showed high correct classification rates in distinguishing IGD and RGU subjects in men and women. Male subjects with versus without IGD showed stronger functional connectivities between and within addiction brain networks. Moreover, the strength of the connectivity within the anticipation network in male IGD subjects was positively related to subjective craving. However, female subjects with versus without IGD showed decreased functional connections between and within addiction brain networks. The strength of connectivity between the anticipation and negative-affect brain networks in female IGD subjects was negatively related to maladaptive cognitive emotion-regulation strategies.
Addiction brain networks have potential for distinguishing IGD and RGU individuals. Importantly, this study identified novel gender-related differences in brain-behavior relationships in IGD. These results help advance current neuroscientific theories of IGD and may inform gender-informed treatment strategies.
与陶醉、负面情绪和预期相关的成瘾大脑网络的异常相互作用可能与网络成瘾障碍（IGD）有关。尽管先前的研究已经确定了 IGD 的神经相关性存在性别差异，但大脑网络的参与仍存在性别差异。
109 名 IGD 患者（54 名男性）和 111 名有娱乐性游戏使用（RGU；58 名男性）提供了静息状态 fMRI 数据。我们检查了成瘾大脑网络在 IGD 与 RGU 受试者中的性别差异。我们进一步比较了成瘾大脑网络之间和内部的连接强度，并探索了成瘾大脑网络内和之间的功能连接强度与几个相关行为测量之间的可能关系。
成瘾大脑网络在区分男性和女性 IGD 和 RGU 受试者方面具有较高的正确分类率。与没有 IGD 的男性相比，患有 IGD 的男性受试者在成瘾大脑网络之间和内部显示出更强的功能连接。此外，男性 IGD 受试者预期网络内的连接强度与主观渴望呈正相关。然而，与没有 IGD 的女性相比，患有 IGD 的女性受试者在成瘾大脑网络之间和内部显示出减少的功能连接。女性 IGD 受试者中预期和负面情绪大脑网络之间的连接强度与适应不良的认知情绪调节策略呈负相关。
成瘾大脑网络具有区分 IGD 和 RGU 个体的潜力。重要的是，本研究确定了 IGD 中与性别相关的大脑-行为关系的新差异。这些结果有助于推进当前的 IGD 神经科学理论，并可能为性别相关的治疗策略提供信息。
