Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air Pollution, Jinan University, Guangzhou, 510632, China.
State Key Laboratory for Chemical Biology and Drug Discovery, Research Institute for Future Food and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation) and Shenzhen Key Laboratory of Food Biological Safety Control, Shenzhen Research Institute of The Hong Kong Polytechnic University, Shenzhen, 518057, China.
Anal Chim Acta. 2022 May 29;1209:339136. doi: 10.1016/j.aca.2021.339136. Epub 2021 Oct 5.
Electrospray ionization (ESI) is a powerful ionization technique in mass spectrometry (MS). There has been an increasing interest for the new development of ESI technique to extend its applications. ESI-MS with wooden tips (wooden-tip ESI-MS), an ESI technique invented in 2011, enabled not only new applications but also new insights into the ESI mechanism. In this review, the technical aspects of wooden-tip ESI-MS are described, the new features of wooden-tip ESI-MS for sampling and ionization of analytes are highlighted, and the important applications of wooden-tip ESI-MS in various fields in the past 10 years, including food safety, forensic investigation, environmental analysis, biomedical analysis and protein study, are summarized. The perspectives on the further development and applications of wooden-tip ESI-MS are also discussed.
电喷雾离子化（ESI）是质谱（MS）中一种强大的离子化技术。人们越来越关注ESI 技术的新发展，以扩展其应用。2011 年发明的 ESI 技术——木针尖电喷雾离子化（wooden-tip ESI-MS）不仅带来了新的应用，也为 ESI 机制提供了新的见解。在这篇综述中，描述了木制尖端 ESI-MS 的技术方面，突出了木制尖端 ESI-MS 在分析物采样和离子化方面的新特点，并总结了木制尖端 ESI-MS 在过去 10 年中在各个领域的重要应用，包括食品安全、法医学调查、环境分析、生物医学分析和蛋白质研究。还讨论了木制尖端 ESI-MS 的进一步发展和应用的展望。
