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1 型糖尿病患者接种严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）疫苗后发生格雷夫斯病。

Graves' Disease after Administration of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine in a Type 1 Diabetes Patient.

机构信息

Department of Diabetes, Endocrinology and Metabolism, Gifu University Graduate School of Medicine, Japan.

Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan.

出版信息

Intern Med. 2022;61(10):1561-1565. doi: 10.2169/internalmedicine.9231-21. Epub 2022 May 15.

DOI:10.2169/internalmedicine.9231-21
PMID:35569928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9177353/
Abstract

Although there is a great demand for increased coronavirus disease 2019 (COVID-19) vaccination worldwide, rare side effects of the vaccine in susceptible individuals are attracting attention. We recently treated a patient with type 1 diabetes who had HLA-A240201/A020101, B5401/B5601, DRB10405/DRB10405, DPB10501/DPB10501 and DQB10401/DQB1040 and developed Graves' disease soon after the administration of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. While causal relationships between vaccinations and adverse events are difficult to discern due to both confounding and masking factors, our findings suggest that attention to possible adjuvant-related endocrinological diseases in certain individuals receiving SARS-CoV-2 vaccines is appropriate.

摘要

尽管全球对 2019 年冠状病毒病（COVID-19）疫苗的需求很大，但疫苗在易感个体中的罕见副作用引起了关注。我们最近治疗了一位患有 1 型糖尿病的患者，该患者 HLA-A240201/A020101、B5401/B5601、DRB10405/DRB10405、DPB10501/DPB10501 和 DQB10401/DQB10401，在接种严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）疫苗后不久就患上了格雷夫斯病。由于混杂和掩盖因素，疫苗接种和不良事件之间的因果关系难以辨别，但我们的发现表明，在接种 SARS-CoV-2 疫苗的某些个体中，应注意可能与佐剂相关的内分泌疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e2/9177353/b01ff53dd370/1349-7235-61-1561-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e2/9177353/ff1dac0eb198/1349-7235-61-1561-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e2/9177353/b01ff53dd370/1349-7235-61-1561-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e2/9177353/ff1dac0eb198/1349-7235-61-1561-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e2/9177353/b01ff53dd370/1349-7235-61-1561-g002.jpg

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