Department of Diabetes, Endocrinology and Metabolism/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Gifu, Japan.
Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kyoto, Japan.
Mod Rheumatol Case Rep. 2023 Jun 19;7(2):378-382. doi: 10.1093/mrcr/rxad008.
Although there is a great demand for increased coronavirus disease 2019vaccination worldwide, rare side effects of the vaccines in susceptible individuals are attracting attention. We recently treated two patients who developed systemic lupus erythematosus after administration of a severe acute respiratory syndrome coronavirus 2 vaccine from Pfizer-BioNTech or Moderna. While causal relationships between vaccination and adverse events are difficult to discern due to both confounding and masking factors, our findings suggest that attention to possible adjuvant-related autoimmune diseases in certain individuals receiving severe acute respiratory syndrome coronavirus 2 vaccines is appropriate.
尽管全球对 2019 年冠状病毒病疫苗的需求很大，但在易感人群中，疫苗的罕见副作用引起了关注。我们最近治疗了两例在接种辉瑞-生物技术公司或 Moderna 的严重急性呼吸综合征冠状病毒 2 疫苗后出现系统性红斑狼疮的患者。由于混杂因素和掩蔽因素，疫苗接种与不良事件之间的因果关系难以辨别，但我们的发现表明，在接种严重急性呼吸综合征冠状病毒 2 疫苗的某些个体中，应注意可能与佐剂相关的自身免疫性疾病。
