Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.
Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Japan.
Intern Med. 2022 Dec 1;61(23):3575-3579. doi: 10.2169/internalmedicine.9545-22. Epub 2022 May 14.
Bing-Neel syndrome (BNS) is a rare central nervous system manifestation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM). We herein report a 62-year-old man with LPL/WM after multiple chemotherapies. He had weakness of lower extremities and elevated serum IgM levels. A bone marrow examination showed lymphoplasmacytic cells infiltration. Contrast-enhanced magnetic resonance imaging suggested enhancing lesions in the cauda equina roots. He was diagnosed with BNS and started on treatment with tirabrutinib 480 mg daily. Within three months, he showed clinical and radiologic improvement. Tirabrutinib may have utility as an effective treatment for BNS.
宾-尼尔综合征（BNS）是淋巴浆细胞淋巴瘤/华氏巨球蛋白血症（LPL/WM）的一种罕见中枢神经系统表现。本文报告了 1 例经多次化疗后发生 LPL/WM 的 62 岁男性，他出现下肢无力和血清 IgM 水平升高，骨髓检查显示淋巴浆细胞浸润，增强磁共振成像提示马尾神经根增强病变。他被诊断为 BNS，并开始接受每日 480mg 的替拉鲁替尼治疗。在 3 个月内，他的临床和影像学均有改善。替拉鲁替尼可能对 BNS 有效。
