Cardiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China.
Endocrinology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China.
Lipids Health Dis. 2022 May 15;21(1):44. doi: 10.1186/s12944-022-01655-5.
Low-density lipoprotein:high-density lipoprotein cholesterol ratio (LDL:HDL ratio) has a good performance in identifying diabetes mellitus (DM) and insulin resistance. However, it is not yet clear whether the LDL:HDL ratio is associated with a high-risk state of prediabetes.
This cohort study retrospectively analyzed the data of 100,309 Chinese adults with normoglycemia at baseline. The outcome event of interest was new-onset prediabetes. Using multivariate Cox regression and smoothing splines to assess the association of LDL:HDL ratio with prediabetes.
During an average observation period of 37.4 months, 12,352 (12.31%) subjects were newly diagnosed with prediabetes. After adequate adjustment for important risk factors, the LDL:HDL ratio was positively correlated with the prediabetes risk, and the sensitivity analysis further suggested the robustness of the results. Additionally, in stratified analysis, we discovered significant interactions between LDL:HDL ratio and family history of DM, sex, body mass index and age (all P-interaction < 0.05); among them, the LDL:HDL ratio-related prediabetes risk decreased with the growth of body mass index and age, and increased significantly in women and people with a family history of DM.
The increased LDL:HDL ratio in the Chinese population indicates an increased risk of developing prediabetes, especially in women, those with a family history of DM, younger adults, and non-obese individuals.
低密度脂蛋白：高密度脂蛋白胆固醇比值（LDL：HDL 比值）在识别糖尿病（DM）和胰岛素抵抗方面表现良好。然而，目前尚不清楚 LDL：HDL 比值是否与糖尿病前期的高危状态有关。
本队列研究回顾性分析了基线时血糖正常的 100309 名中国成年人的数据。感兴趣的结局事件是新发糖尿病前期。使用多变量 Cox 回归和平滑样条评估 LDL：HDL 比值与糖尿病前期的关系。
在平均 37.4 个月的观察期内，12352 名（12.31%）受试者新诊断为糖尿病前期。在充分调整重要危险因素后，LDL：HDL 比值与糖尿病前期风险呈正相关，敏感性分析进一步表明结果稳健。此外，在分层分析中，我们发现 LDL：HDL 比值与糖尿病家族史、性别、体重指数和年龄之间存在显著交互作用（所有 P 交互作用<0.05）；其中，随着体重指数和年龄的增长，LDL：HDL 比值相关的糖尿病前期风险降低，而在女性和有糖尿病家族史的人群中则显著增加。
中国人群 LDL：HDL 比值的升高表明发生糖尿病前期的风险增加，尤其是在女性、有糖尿病家族史、年轻人群和非肥胖人群中。
