Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Mini Rev Med Chem. 2022;22(22):2847-2863. doi: 10.2174/1389557522666220513120828.
Ginsenosides, the essential active ingredients extracted from ginseng, have been well studied in the past several decades because of their numerous pharmacological properties including anti-tumor, anti-inflammatory, and anti-diabetic activities, as well as hepatoprotection, skin protection, and memory improvement, etc. Compound-K (CK) is the major metabolite derived from the deglycosylation of ginsenosides by intestinal bacteria and has been proved to be the actual active entity absorbed into the systemic circulation. In this review, we comprehensively elucidate the pharmacological activities of CK from the molecular mechanism, as well as its structurally modified derivatives. We hope this review would be helpful to get a systematic summary and provide constructive insights for the further research of CK.
人参中的主要活性成分——人参皂苷，在过去几十年中因其具有多种药理活性而得到广泛研究，包括抗肿瘤、抗炎、抗糖尿病作用，以及肝保护、皮肤保护和改善记忆等作用。化合物 K（CK）是肠道细菌对人参皂苷进行去糖基化后衍生的主要代谢产物，已被证实是被系统吸收的实际有效成分。本综述从分子机制以及结构修饰衍生物的角度全面阐述了 CK 的药理活性。我们希望本综述能为 CK 的进一步研究提供系统的总结和有价值的见解。
