From the Department of Pediatric Nephrology, Başkent University Faculty of Medicine, Ankara, Turkey.
Exp Clin Transplant. 2022 May;20(Suppl 3):39-44. doi: 10.6002/ect.PediatricSymp2022.O6.
The association between vitamin D deficiency and anemia is known. Vitamin D deficiency and anemia are common in kidney transplant recipients. We examined the relationship between vitamin D levels and anemia in pediatric kidney transplant recipients.
We reviewed retrospectively the data of 75 pediatric kidney transplant recipients (0-18 years of age). Patients were evaluated in 3 groups according to serum 25-hydroxyvitamin D levels (<20, 20-30, and >30 ng/mL) in the first year posttransplant: group 1 was the vitamin D deficiency group, group 2 was the vitamin D insufficiency group, and group 3 was normal vitamin D level group, respectively. Groups were compared in terms of anemia parameters, calcium, phosphorus, alkaline phosphatase, and parathyroid hormone levels, as well as infection, rejection, and graft loss status. All patients included in the study were grouped as those with anemia and without anemia, and the 2 groups were compared in terms of vitamin D levels, serum parathyroid hormone values, estimated glomerular filtration rate, and infection, rejection, and graft loss status.
There were 41 patients (54.7%) in group 1, 24 patients (32%) in group 2, and 10 patients (13%) in group 3. There were 65 patients (86.7%) with vitamin D deficiency/insufficiency. When groups were compared, the hematocrit level was found to be lower in groups 1 and 2 (P < .05) and ferritin level was found to be lower in group 1 (P < .05). Anemia was present in 20 patients (26.6%): 61% of patients with anemia had vitamin D deficiency and 33% had vitamin D insufficiency (P > .05). In total, 94% of patients with anemia had vitamin D deficiency/insufficiency.
Vitamin D deficiency/insufficiency is common in pediatric kidney transplant recipients. Vitamin D levels should be measured, especially in all kidney transplant recipients with persistent anemia. Thus, risk factors associated anemia can be reduced by treating the deficiency/insufficiency.
已知维生素 D 缺乏与贫血有关。维生素 D 缺乏和贫血在肾移植受者中很常见。我们研究了儿童肾移植受者维生素 D 水平与贫血之间的关系。
我们回顾性分析了 75 例儿童肾移植受者（0-18 岁）的数据。根据移植后第一年血清 25-羟维生素 D 水平（<20、20-30 和>30ng/ml），将患者分为 3 组：第 1 组为维生素 D 缺乏组，第 2 组为维生素 D 不足组，第 3 组为正常维生素 D 水平组。比较各组贫血参数、钙、磷、碱性磷酸酶和甲状旁腺激素水平以及感染、排斥和移植物丢失情况。将所有纳入研究的患者分为贫血组和无贫血组，比较两组维生素 D 水平、血清甲状旁腺激素值、估计肾小球滤过率以及感染、排斥和移植物丢失情况。
第 1 组 41 例（54.7%），第 2 组 24 例（32%），第 3 组 10 例（13%）。维生素 D 缺乏/不足 65 例（86.7%）。组间比较发现，第 1 组和第 2 组的红细胞压积水平较低（P<0.05），第 1 组的铁蛋白水平较低（P<0.05）。20 例患者（26.6%）存在贫血：贫血患者中 61%有维生素 D 缺乏，33%有维生素 D 不足（P>0.05）。总共有 94%的贫血患者存在维生素 D 缺乏/不足。
儿童肾移植受者中维生素 D 缺乏/不足很常见。应测量维生素 D 水平，尤其是所有持续贫血的肾移植受者。因此，通过治疗缺乏/不足可以降低与贫血相关的风险因素。
