Eales J G, Ranson M, Shostak S, Primeau D
Gen Comp Endocrinol. 1986 Sep;63(3):393-9. doi: 10.1016/0016-6480(86)90138-3.
Plasma levels of L-thyroxine (T4) and 3,5,3'-triiodo-L-thyronine (T3) were measured in arctic charr at 2, 6, or 24 hr after single intraperitoneal injection of epinephrine (E) or norepinephrine (NE). At a dose of approximately 1 microgram/g body wt (sufficient to cause a submaximal dermal melanophore pallor response) plasma T4 was usually elevated at 2 hr, consistently depressed at 6 hr, and unaffected at 24 hr. There was no effect of E on plasma [125I]T4 kinetics or [125I]T4 5'-monodeiodination to [125I]T3. Plasma T3 showed no consistent response to E or NE at any sampling time. At an E dose of 4 ng/g body wt (probably sufficient to cause a physiological elevation in plasma E level), neither plasma T4 nor T3 levels were altered at 6 hr. Acute depression in plasma T4 by the high doses of E and NE may reflect a local neurotransmitter role of catecholamines in inhibiting thyroidal T4 release through action at thyroidal, hypophysial, or hypothalamic levels.
在北极红点鲑单次腹腔注射肾上腺素（E）或去甲肾上腺素（NE）后2、6或24小时，测量其血浆中L-甲状腺素（T4）和3,5,3'-三碘-L-甲状腺原氨酸（T3）的水平。在剂量约为1微克/克体重（足以引起次最大程度的皮肤黑素细胞苍白反应）时，血浆T4通常在2小时时升高，在6小时时持续降低，在24小时时无影响。E对血浆[125I]T4动力学或[125I]T4向[125I]T3的5'-单碘化无影响。在任何采样时间，血浆T3对E或NE均未表现出一致的反应。在E剂量为4纳克/克体重时（可能足以引起血浆E水平的生理性升高），6小时时血浆T4和T3水平均未改变。高剂量的E和NE导致血浆T4急性降低，可能反映了儿茶酚胺在甲状腺、垂体或下丘脑水平通过作用抑制甲状腺T4释放的局部神经递质作用。
