Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Oxid Med Cell Longev. 2022 May 6;2022:2504798. doi: 10.1155/2022/2504798. eCollection 2022.
Stroke is one of the leading causes of death and disability in the world. However, the pathophysiological process of stroke is still not fully clarified. Mitochondria play an important role in promoting nerve survival and are an important drug target for the treatment of stroke. Mitochondrial dysfunction is one of the hallmarks of stroke. Mitochondria are in a state of continuous fission and fusion, which are termed as mitochondrial dynamics. Mitochondrial dynamics are very important for maintaining various functions of mitochondria. In this review, we will introduce the structure and functions of mitochondrial fission and fusion related proteins and discuss their role in the pathophysiologic process of stroke. A better understanding of mitochondrial dynamin in stroke will pave way for the development of new therapeutic options.
中风是世界上导致死亡和残疾的主要原因之一。然而，中风的病理生理过程仍未完全阐明。线粒体在促进神经存活方面发挥着重要作用，是治疗中风的重要药物靶点。线粒体功能障碍是中风的标志之一。线粒体处于不断分裂和融合的状态，这被称为线粒体动力学。线粒体动力学对于维持线粒体的各种功能非常重要。在这篇综述中，我们将介绍与线粒体分裂和融合相关蛋白的结构和功能，并讨论它们在中风病理生理过程中的作用。更好地了解中风中的线粒体动力蛋白将为开发新的治疗选择铺平道路。
